Intern: Ocular PBPK & ADC Translational Modeling

Genmab; Utrecht; Hybrid; EUR 8,000 - 9,000; Full time

Benefits offered by this job

Pension

Health insurance

Paid time off

Employee support programs

Job summary

Genmab in Utrecht, Netherlands, offers a 6–12 month internship in quantitative pharmacology and translational modeling. You will build a mechanistic ocular PBPK framework for ADCs and payloads, connecting systemic kinetics to eye compartments.

The role requires master’s enrollment and strong PK modeling skills, with a hybrid work arrangement. You will calibrate the model with case studies, review ocular PK models, and deliver reproducible code, data, figures, and a manuscript-ready report in

Qualifications

• Currently enrolled in a Dutch university Master’s program in pharmacometrics, pharmaceutical sciences, biomedical engineering, systems biology, quantitative biology, bioinformatics, toxicology, biomedical sciences, or related field.
• Internship must be a formal, mandatory component of degree; not for graduates or extracurricular internships.
• Minimum 6 months; 9–12 months preferred.
• Experience with R or Python and interest in mechanistic PK modeling.

Responsibilities

• Conduct structured literature reviews on cytotoxic agents, ADC payloads, and ocular toxicity patterns.
• Build a curated evidence base covering ocular adverse events, PK data, and tissue data.
• Review published ocular PK/BiPK models and define a fit-for-purpose ADC/payload model structure.
• Implement an ocular PBPK model in R or equivalent, linking systemic kinetics to eye compartments.
• Calibrate and evaluate the framework across case studies with different targets and payloads.
• Perform sensitivity analyses to identify drivers of local ocular exposure and toxicity mechanisms.
• Run prospective design scenarios to assess payload properties and dosing impact on ocular exposure.
• Translate results into a practical risk‑assessment workflow for ADC design.

Skills

R or Python experience

Mechanistic PK modeling

PBPK/ODE familiarity

Education

Master's degree program (Dutch university)

Tools

RxODE2

mrgsolve

PK-Sim

R

Job description

Genmab in Utrecht, Netherlands, offers a 6–12 month internship in quantitative pharmacology and translational modeling. You will build a mechanistic ocular PBPK framework for ADCs and payloads, connecting systemic kinetics to eye compartments.

The role requires master’s enrollment and strong PK modeling skills, with a hybrid work arrangement. You will calibrate the model with case studies, review ocular PK models, and deliver reproducible code, data, figures, and a manuscript-ready report in