Intern, Clinical Pharmacology & Quantitative Science

Genmab; Utrecht; Hybrid; EUR 8,000 - 9,000; Full time

Benefits offered by this job

Pension

Health insurance and wellness benefits

Paid time off

Employee support programs

Job summary

Genmab in Utrecht, the Netherlands, offers a Master’s internship in Quantitative Translational Pharmacology. You will integrate a tumor growth inhibition module into Genmab's PBPK/PD framework and work with diverse datasets to advance translational modeling.

The role emphasizes a mandatory university placement for 6–12 months, with hybrid work (3 days in the office, 2 days remote). Strong biology, math, and programming skills are valued.

Qualifications

• Enrollment in a Master's programme in Biopharmaceutical Sciences, Biomedical Sciences, Drug Innovation, Pharmacy, or another relevant discipline in the Netherlands.
• This internship must be a mandatory component of your degree for graduation.
• Strong analytical thinking and a proactive approach to problem solving.
• Excellent communication skills in English and collaboration in multidisciplinary teams.

Responsibilities

• During your internship, you will implement a tumor growth inhibition model within Genmab's translational PBPK/PD framework.
• Compile, curate, and analyze in vitro, preclinical, and clinical data to support translational modeling.
• Compare in vitro-only and combined in vitro/in vivo strategies for predicting efficacious patient exposure.
• Investigate opportunities to reduce or refine preclinical animal studies through quantitative modeling.
• Present your findings through clear reports and presentations to colleagues within the team.

Skills

R programming

PK/PD modeling

PBPK modeling

QSP modeling

Cancer biology

Immunology basics

English communication

Education

Master's program in Biopharmaceutical Sciences, Biomedical Sciences, Drug Innovation, Pharmacy, or related in the Netherlands

Job description

At Genmab, we are dedicated to building extra[not]ordinary® futures, together, by developing antibody products and groundbreaking, knock-your-socks-off KYSO antibody medicines® that change lives and the future of cancer treatment and serious diseases. We strive to create, champion and maintain a global workplace where individuals’ unique contributions are valued and drive innovative solutions to meet the needs of our patients, care partners, families and employees.

Our people are compassionate, candid, and purposeful, and our business is innovative and rooted in science. We believe that being proudly authentic and determined to be our best is essential to fulfilling our purpose. Yes, our work is incredibly serious and impactful, but we have big ambitions, bring a ton of care to pursuing them, and have a lot of fun while doing so.

Does this inspire you and feel like a fit? Then we would love to have you join us!

The Role

Can quantitative modeling help reduce the need for animal studies in drug development? While in vitro assays provide valuable mechanistic insights, they do not always fully predict how a therapy will perform in vivo. Animal studies can bridge that gap, but they are time-consuming, resource-intensive, and should only be used where they truly add scientific value.

Within Genmab's Quantitative Translational Pharmacology team, you will contribute to an exciting project that explores how quantitative modeling can help optimize this process. By combining historical preclinical and clinical data, you will investigate whether in vivo tumor growth inhibition studies improve the prediction of efficacious patient exposure compared with an in vitro-only approach. Ultimately, the goal is to support smarter drug development decisions while contributing to the 3Rs principles (Replacement, Reduction and Refinement) by identifying opportunities to reduce or refine the use of animal studies.

During this internship, you will integrate a tumor growth inhibition module into Genmab's translational PBPK/PD modeling framework and work with a diverse range of datasets, including molecular and cellular assays, pharmacokinetic data, tumor growth inhibition studies, and clinical exposure-response data. Your work will contribute to the development of a reusable modeling workflow that can support future discovery projects.

You will become part of an experienced multidisciplinary team where you'll receive guidance while also having the opportunity to work independently. The exact direction of the project can be tailored to your interests and academic background, allowing you to deepen your expertise in quantitative pharmacology within a dynamic biotechnology environment.

If you're passionate about quantitative modeling, drug development, and using data to answer complex biological questions, we'd love to see your application!

Responsibilities

During your internship, you will:

• Implement a tumor growth inhibition model within Genmab's translational PBPK/PD modeling framework.
• Compile, curate, and analyze in vitro, preclinical, and clinical datasets to support translational modeling.
• Compare in vitro-only and combined in vitro/in vivo strategies for predicting efficacious patient exposure.
• Investigate opportunities to reduce or refine preclinical animal studies through quantitative modeling.
• Perform exploratory data analyses and evaluate model performance using appropriate diagnostics.
• Present your findings through clear reports and presentations to colleagues within the team.
  
  

Requirements

We're looking for a curious and motivated Master's student who enjoys combining biology, mathematics, and programming to solve complex scientific questions. You also bring:

• Enrollment in a Master's programme in Biopharmaceutical Sciences, Biomedical Sciences, Drug Innovation, Pharmacy, or another relevant discipline at a university in the Netherlands.
• This internship must be a mandatory component of your degree programme required for graduation. Unfortunately, we cannot consider applications from graduates or students seeking an extracurricular internship.
• Basic knowledge of cancer biology and/or immunology.
• Familiarity with PK/PD, PBPK, and/or QSP modeling, including model calibration and evaluation.
• Experience with programming, preferably in R.
• An interest in quantitative modeling and translational pharmacology.
• Strong analytical thinking and a proactive approach to problem solving.
• Excellent communication skills in English and the ability to collaborate in multidisciplinary teams.
• Experience with nonlinear mixed-effects modeling or previous industry experience is considered an advantage but is not required.
  
  

General Internship Information

• Duration: 6-12 months
• Start date: 1 November
• Location: Utrecht, the Netherlands
• Working pattern: Hybrid (3 days in the office, 2 days working from home)
  
  

The proposed gross annual/monthly base salary range for this position, in the primary location, based on a full time schedule is:

EUR750,00---750,00

The final salary offer will depend on several factors, including your skills, qualifications, and experience.

In addition to base salary, this position is eligible for additional forms of compensation, such as discretionary bonuses and long-term incentives.

Benefits

When you join Genmab, you become a part of a culture that supports your physical, financial, social, and emotional well-being. Our benefits include, but are not limited to:

• Pension
• Health insurance and wellness benefits
• Paid time off
• Employee support programs
  
  

Further details on eligibility for compensation and benefits based on the role will be provided during the recruitment process.

About Genmab

Genmab is an international biotechnology company with a core purpose to improve the lives of patients through innovative and differentiated antibody therapeutics. For 25 years, its hard-working, innovative and collaborative team has invented next-generation antibody technology platforms and harnessed translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO®) antibody medicines.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X.

Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on our website Job Applicant Privacy Notice (genmab.com).

Please note that if you are applying for a position in the Netherlands, Genmab’s policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the contract.