Jobs in Sunderland, United States

Principal Scientist – Non-Clinical PKPD (Contract)
UK (Slough-based, VDI only – remote access provided) | 12-month contract |Full-time (37.5 hrs/week) | £35.20–£47.92/hr (PAYE/LTD/Umbrella)

We are supporting a global biopharma organisation seeking an experienced Principal Scientist, Non-Clinical PKPD to join their Early Clinical Development & Translational Sciences group on a 12-month contract.

This role sits within the Quantitative Clinical Pharmacology function, which integrates PK/PD, systems modelling, clinical pharmacology, and DMPK approaches across the full drug development lifecycle. The position offers an excellent opportunity for a skilled pharmacokinetics/pharmacodynamics scientist to contribute to innovative drug development projects from preclinical through regulatory submission.

• Lead strategy and execution of non-clinical PKPD and GLP toxicokinetic studies.

• Provide scientific input into study protocols and regulatory study designs.

• Collaborate cross-functionally with Non-Clinical Safety, Bioanalysis, Clinical Pharmacology, and external CRO partners.

• Ensure delivery of high-quality data packages that meet GLP and regulatory submission standards.

• Analyse, interpret, and report PKPD/toxicokinetic study results; deliver reports and summaries for regulatory submissions.

• Effectively communicate interim and final results to project teams and stakeholders.

• Represent the function internally and externally, contributing to scientific reputation and best practices.

• PhD, MSc, or BSc in pharmacology, quantitative pharmacology, pharmacokinetics/pharmacodynamics, DMPK, or related field.

• 5+ years’ hands-on PKPD data analysis experience within pharma or CRO environments.

• Strong knowledge of pharmacology and drug mechanisms.

• Proven ability to design and deliver non-clinical PKPD studies and GLP toxicokinetics reports.

• Proficiency with Phoenix WinNonlin is essential; experience with modelling/simulation tools (e.g., Berkeley Madonna, R) a plus.

• Track record of regulatory submissions and/or scientific publications desirable.

• Strong communication skills with the ability to influence and collaborate in a matrix environment.

• Duration: 12 months (potential extension).

• Hours: 37.5 per week (7.5 per day).

• Location: UK-based; virtual desktop infrastructure (VDI only). Candidate provides own equipment. Future office relocation to Surrey anticipated in 2026/27.