Senior Scientist, Synthetic Genomics & Genome Design

Constructive Bio; Cambridge; In loco; GBP 70.000 - 100.000; Tempo pieno

Vantaggi offerti da questo lavoro

Annual bonus

Holiday entitlement

Pension matching

Private medical insurance

On-site parking

Descrizione del lavoro

Constructive Bio in Cambridge is seeking a Scientist or Senior Scientist in Synthetic Genomics to design and execute experiments supporting our proprietary genome synthesis and large DNA assembly technologies. The role focuses on creating synthetic microorganisms with reprogrammed genetic codes to enable recombinant production of proteins with non-canonical monomers.

The ideal candidate will have a PhD and hands-on experience in genetic design, DNA cloning, and data interpretation, with a track

Competenze

• PhD or equivalent experience in molecular biology, microbiology, biochemistry, bioengineering or a related field.
• Proficiency in designing and executing DNA cloning, including Gibson, Golden Gate or similar.
• Engineering mindset with experience designing, building and troubleshooting genetic systems.
• Experience analyzing sequencing data (Illumina/Oxford Nanopore).
• Familiarity with DNA manipulation in prokaryotes (base editing, recombination, conjugation).
• Strong problem-solving and independent working style; excellent communication skills.

Mansioni

• Deploy and develop our genome synthesis platform for constructing microorganisms controlled by synthetic genomes.
• Conceive and execute experiments to optimize growth and production phenotypes.
• Stay up to date with DNA synthesis, assembly, and genome engineering technologies.
• Record, analyse and communicate progress, results and challenges to R&D and leadership.
• Collaborate with experimental and computational colleagues to deliver timely results.

Conoscenze

PhD or equivalent background

Experimental design

Problem solving

Communication skills

Formazione

PhD

Strumenti

Gibson assembly

Golden Gate assembly

Descrizione del lavoro

Constructive Bio in Cambridge is seeking a Scientist or Senior Scientist in Synthetic Genomics to design and execute experiments supporting our proprietary genome synthesis and large DNA assembly technologies. The role focuses on creating synthetic microorganisms with reprogrammed genetic codes to enable recombinant production of proteins with non-canonical monomers.

The ideal candidate will have a PhD and hands-on experience in genetic design, DNA cloning, and data interpretation, with a track