Genomics Data Scientist, Functional Genomics — Hybrid London

Substrate Bio Ltd; Greater London; Presencial; GBP 90.000 - 130.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

30 days annual leave

Pension 10% employer contribution

Bupa private health cover

Descripción de la vacante

Substrate Bio Ltd in London is seeking a senior computational biologist to own the analysis of functional genomics data, collaborating with scientists designing and running CRISPR screens and multi-omics readouts.

You will build pipelines, QC, differential expression, and integrate proteomics, transcriptomics, and imaging readouts, ensuring reproducibility with the software team. The role is on-site at King’s Cross with regular lab time.

Formación

• A PhD, or a master’s with two to three years of relevant experience, in genomics, bioinformatics, computational biology, statistics or a related field.
• Strong Python or R, with good engineering habits such as Git, code review and reproducible workflows, and working with coding agents.
• Hands‑on single‑cell RNA‑seq analysis, for example with Scanpy or Seurat, including CRISPR screen QC such as guide assignment and knockdown efficiency.
• Statistical and machine learning methods on biological data, including linear and mixed models, multiple testing, and handling batch effects and confounders.
• Working closely with wet‑lab scientists, and explaining results clearly to people outside your field.

Responsabilidades

• Own the analysis of functional genomics data and build pipelines that scale with throughput.
• Perform QC, guide assignment, differential expression analysis and modelling of perturbation effects.
• Develop an image‑based profiling pipeline and integrate multi‑omic readouts.
• Present results with uncertainty and QC to scientists and leadership, and collaborate with the software team to ensure reproducibility.

Conocimientos

Python or R

Git

scRNA-seq

Statistics & ML

Interdisciplinary collaboration

Educación

PhD or MSc with 2-3 years

Herramientas

Nextflow

Snakemake

Docker

AWS

Descripción del empleo

Substrate Bio Ltd in London is seeking a senior computational biologist to own the analysis of functional genomics data, collaborating with scientists designing and running CRISPR screens and multi-omics readouts.

You will build pipelines, QC, differential expression, and integrate proteomics, transcriptomics, and imaging readouts, ensuring reproducibility with the software team. The role is on-site at King’s Cross with regular lab time.