Scientist/Senior Scientist Synthetic Genomics

Constructive Bio; Cambridge; In loco; GBP 70.000 - 100.000; Tempo pieno

Vantaggi offerti da questo lavoro

Annual bonus

Holiday entitlement

Pension matching

Private medical insurance

On-site parking

Descrizione del lavoro

Constructive Bio in Cambridge is seeking a Scientist or Senior Scientist in Synthetic Genomics to design and execute experiments supporting our proprietary genome synthesis and large DNA assembly technologies. The role focuses on creating synthetic microorganisms with reprogrammed genetic codes to enable recombinant production of proteins with non-canonical monomers.

The ideal candidate will have a PhD and hands-on experience in genetic design, DNA cloning, and data interpretation, with a track

Competenze

• PhD or equivalent experience in molecular biology, microbiology, biochemistry, bioengineering or a related field.
• Proficiency in designing and executing DNA cloning, including Gibson, Golden Gate or similar.
• Engineering mindset with experience designing, building and troubleshooting genetic systems.
• Experience analyzing sequencing data (Illumina/Oxford Nanopore).
• Familiarity with DNA manipulation in prokaryotes (base editing, recombination, conjugation).
• Strong problem-solving and independent working style; excellent communication skills.

Mansioni

• Deploy and develop our genome synthesis platform for constructing microorganisms controlled by synthetic genomes.
• Conceive and execute experiments to optimize growth and production phenotypes.
• Stay up to date with DNA synthesis, assembly, and genome engineering technologies.
• Record, analyse and communicate progress, results and challenges to R&D and leadership.
• Collaborate with experimental and computational colleagues to deliver timely results.

Conoscenze

PhD or equivalent background

Experimental design

Problem solving

Communication skills

Formazione

PhD

Strumenti

Gibson assembly

Golden Gate assembly

Descrizione del lavoro

Who we are:

Constructive Bio is a growing Cambridge based biotechnology company built on a simple conviction: the molecules that matter most are often the ones that can’t yet be made.

We’ve rewritten the genetic code to give cells access to newncAA chemical building blocks - expanding the space of proteins that can be designed, engineered, and manufactured. Our platform moves from unexplored molecular territory to industrial-scale production, turning scientific possibility into manufacturable reality.

From next-generation medicines to advanced materials, Constructive shifts the question from “can we make this?” to “what should we make next?”

We’re proud to be aspinout from Professor Jason Chin's laboratory at the MRC Laboratory of Molecular Biology in Cambridge. You can learn more about the Chin lab achievements here.

Since launching in 2022, Constructive Bio has raised $73 million in venture capital, including a $15 million seed round and a $58 million Series A, to commercialise our breakthrough synthetic genomics platform. Today, we are advancing a growing pipeline of programmes based on world-leading science, enabling the precise engineering of biology to create transformative medicines, materials and sustainable products.

As a fast-growing biotech at the forefront of generative biology,we're building a team of exceptional people who share our ambition to redefine what's possible with biology.

Join us and help shape the future of biology.

What we are looking for:

The Scientist, Synthetic Genomics will design and execute experimental strategies that support the development of our proprietary technologies for genome synthesis and large DNA assembly, with a focus on the creation of synthetic microorganisms with reprogrammed genetic codes that enable the recombinant production of valuable proteins and peptides containing multiple different non-canonical monomers. The role contributes to our platform through robust experimental design, thorough documentation, problem-solving, and collaboration with scientists, engineers and bioinformaticians. The ideal candidate will have a background in biological engineering and a proven track record of designing, executing and documenting experiments. The post holder will have the opportunity to make a significant impact on the next stage of our platform development.

This role is open at either Scientist or Senior Scientist level. We will determine the level at offer stage based on depth of experience, scope of independent ownership, and leadership contribution.

Key responsibilities

• Deploy and develop our proprietary genome synthesis platform for the construction of microorganisms controlled by computationally designed, chemically synthesized genomes
• Independently conceive and execute experimental strategies for optimizing the growth and production phenotypes of strains with reprogrammed genetic codes
• Stay up to date with cutting-edge technologies in DNA synthesis, DNA assembly and large-scale genome engineering
• Record, analyse and interpret data, and regularly communicate progress, results and challenges to the wider R&D and leadership teams
• Collaborate closely with experimental and computational colleagues to deliver results on time and in line with the company's objectives

About you

• PhD or equivalent experience in molecular biology, microbiology, biochemistry, bioengineering or a related field
• Proficiency in the design and execution of DNA cloning, including Gibson, Golden Gate assembly or similar
• An engineering mindset, and experience in designing, building and troubleshooting genetic systems for target outputs
• Experience analysing and interpreting next-generation sequencing data, particularly Illumina and/or Oxford Nanopore
• Familiarity with techniques for DNA manipulation in prokaryotes, such as base editing, homologous recombination, conjugation, transduction and transposition
• Strong problem-solving skills and the ability to work independently in a collaborative environment with shifting priorities
• Excellent written and oral communication skills

Nice to have

• Good working knowledge of bacterial genetics, genome annotation tools and genomic databases
• Familiarity with in vivo DNA assembly workflows in E. coli, Saccharomyces cerevisiae or other microorganisms
• Familiarity with laboratory automation equipment and high-throughput molecular biology workflows
• Familiarity with Benchling or a comparable ELN

Other details

• Laboratory-based at our site in Whittlesford, South Cambridgeshire
• This is a laboratory-based role. Day-to-day work involves extended periods of bench work in a shared microbiology laboratory, including manual handling of equipment and consumables. We are committed to making reasonable adjustments to support candidates and employees in performing the role, and encourage you to contact us to discuss any adjustments you may need.

Salary and benefits:

• Competitive salary
• Discretionary annual performance bonus
• 25 days holiday plus bank holidays
• Company pension (matching up to 8%), life assurance, private medical insurance and group income protection schemes
• Opportunity to be part of our employee long term incentive scheme
• Newly fitted, purpose-built facilities in Whittlesford, South Cambridge, with on-site parking and excellent rail links to Cambridge,Londonand Norwich
• A collaborative and pioneering environment at the cutting edge of synthetic genomics and engineered translation

Please note that our office space is dog friendly.

Our principles:

We are committed to building a culture founded on trust, respect and collaboration, where curiosity, openness and scientific excellence thrive.

• We imagine: We think big and plan our own path for success.
• We pioneer: Wetake actionand grow together as one to break moulds.
• We deliver: We take ownership and work together to deliver excellence.

Constructive Bio is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.