Senior Scientist, Protein Expression & Purification Lead

LabGenius; Greater London; On-site; GBP 90,000 - 135,000; Full time

Benefits offered by this job

Discretionary bonus

Equity stock options

Pension plan 5% company contribution

Life insurance

Job summary

LabGenius is seeking a PhD-level protein sciences expert to lead expression and purification workflows for our antibody assets. You will build and scale our CHO-based production, establish stable cell lines, and ensure high-quality reagents for ML-driven screening.

You will troubleshoot bottlenecks, optimize gene-to-protein workflows, and coordinate with wet-lab and data teams to deliver robust, scalable expression solutions at multi-milligram to gram scales.

Qualifications

• PhD in Biochemistry, Bioengineering, Molecular Biology, or MSc with 3–5 years industrial wet-lab experience.
• Hands-on mastery of mammalian cell culture techniques, especially CHO and HEK for transient expression and stable pools.
• Proven track record in molecular cloning and large-scale DNA production for transfections.
• Extensive experience with FPLC systems (AKTA) and protein biochemistry.
• Ability to design and implement new lab infrastructure and gene-to-protein workflows.
• Willingness to learn new skills and work in a multidisciplinary team.
• Ability to communicate complex protein production data to non-experts.
• Strong organizational and time-management skills.
• Experience with digital inventory management and barcoding of samples and cell banks.
• Self-motivated with a positive attitude and impact-driven approach.
• Experience working in a multidisciplinary business context.

Responsibilities

• Lead transient expression of complex recombinant proteins in mammalian hosts at multi‑mg to g scales.
• Oversee cloning and large-scale DNA production to support transfections and stable lines.
• Establish and validate stable CHO cell pools for lead antibodies.
• Design and execute multi-step purification strategies using AKTA systems (Affinity, IEX, HIC, SEC).
• Implement inventory management and barcoding for end-to-end traceability.
• Collaborate with Data Science to convert expression and purity data into ML-friendly datasets.
• Troubleshoot low-yielding constructs and optimise signal peptides, vectors, and host lines.
• Maintain meticulous experimental records for cross-functional teams.
• Balance priorities to deliver on timelines.

Skills

Mammalian cell culture

Protein expression

Molecular cloning

DNA production

FPLC AKTA

Data interpretation

Project management

Education

PhD in Biochemistry

PhD in Bioengineering

PhD in Molecular Biology

MSc with 3–5 years wet-lab experience

Tools

AKTA FPLC

Job description

LabGenius is seeking a PhD-level protein sciences expert to lead expression and purification workflows for our antibody assets. You will build and scale our CHO-based production, establish stable cell lines, and ensure high-quality reagents for ML-driven screening.

You will troubleshoot bottlenecks, optimize gene-to-protein workflows, and coordinate with wet-lab and data teams to deliver robust, scalable expression solutions at multi-milligram to gram scales.