Senior CHO Protein Expression & Purification Scientist

LabGenius Limited; Greater London; On-site; GBP 70,000 - 100,000; Full time

Benefits offered by this job

Discretionary bonus

Equity

Pension: company contribution

Private medical insurance

Health cashback

GP access

Gym discounts

Cycle to Work

25 days annual leave

Job summary

LabGenius Therapeutics in London seeks a Protein Expressions Lead to drive high‑quality expression and purification of complex proteins. You will scale from cloning to purification, establish stable CHO pools, and ensure clean datasets for ML/AI models.

You will work within a core wet‑lab team, troubleshoot bottlenecks, and collaborate closely with Data Science and engineering to advance therapeutic antibodies toward developability and scalable production.

Qualifications

• PhD in Biochemistry, Bioengineering, Molecular Biology, or MSc with 3–5 years of wet-lab protein expression experience.
• Hands-on mastery of mammalian cell culture, CHO and HEK lines for transient and stable pools.
• Molecular cloning, vector design, and high‑quality DNA production for transfections.
• Experience with FPLC systems (AKTA) and protein biochemistry concepts.
• Ability to translate protein data for ML/AI models and collaborate cross‑functionally.
• Strong organizational and time management skills, and meticulous record keeping.

Responsibilities

• Lead transient expression of complex recombinant proteins, bispecifics and fusion proteins in mammalian hosts at multi‑milligram to gram scales.
• Oversee cloning, construct design, and large‑scale DNA production for transfections and stable pools.
• Establish and validate CHO stable cell lines for lead antibody production.
• Design and execute multi‑step purification using AKTA with Affinity, IEX, HIC, SEC.
• Manage inventory and barcoding to ensure traceability of plasmids, cell lines, and proteins.
• Collaborate with Data Science to translate yields and purity data into ML/AI datasets.
• Troubleshoot low yields and optimize constructs, expression vectors, or host lines.
• Maintain thorough experimental records for cross‑functional teams.
• Balance priorities to meet timelines across the team.

Job description

LabGenius Therapeutics in London seeks a Protein Expressions Lead to drive high‑quality expression and purification of complex proteins. You will scale from cloning to purification, establish stable CHO pools, and ensure clean datasets for ML/AI models.

You will work within a core wet‑lab team, troubleshoot bottlenecks, and collaborate closely with Data Science and engineering to advance therapeutic antibodies toward developability and scalable production.