Senior Scientist, Protein Expression & Purification (CHO)

LabGenius Therapeutics; Greater London; On-site; GBP 80,000 - 120,000; Full time

Benefits offered by this job

Discretionary bonus

Stock options

Pension plan

Life assurance

Private medical insurance

Gym discounts

25 days annual leave

Job summary

LabGenius Therapeutics in London is seeking a protein expression lead to drive the gene-to-protein workflow from cloning to large-scale purification, ensuring ultra-pure reagents feed ML models. You will spearhead stable CHO cell line development and troubleshoot complex constructs with a cross-disciplinary team.

You will collaborate with Data Science and wet-lab colleagues to scale production while maintaining rigorous data records and project timelines.

Qualifications

• PhD in Biochemistry/Bioengineering/Molecular Biology or MSc with 3–5 years of industrial wet-lab experience.
• Deep hands-on mammalian cell culture expertise, CHO/HEK for transient and stable pool generation.
• Proven experience in molecular cloning, vector optimisation, and large-scale DNA production for transfections.
• Extensive experience with FPLC systems (AKTA) and a strong grasp of protein biochemistry and folding.
• Ability to design/setup new lab infrastructure and optimize gene-to-protein workflows.

Responsibilities

• Lead transient expression of complex recombinant proteins and fusions in mammalian hosts at multi-milligram to gram scales.
• Oversee cloning, construct design, and large-scale plasmid DNA production for transfections and stable pools.
• Establish and validate internal stable cell line capabilities (CHO) for lead candidates.
• Design and implement multi-step purification strategies using AKTA-based systems (Affinity, IEX, HIC, SEC).
• Maintain robust inventory management and barcoding for samples, cell banks, and reagents.
• Collaborate with Data Science to translate yields, purity, and biophysical data into ML-ready datasets.
• Troubleshoot low-yield constructs and optimize signal peptides, vectors, or host lines.
• Keep meticulous records and manage timelines across cross-functional teams.

Skills

Mammalian cell culture

Molecular cloning

Protein expression

Data interpretation

Time management

Education

PhD in Biochemistry/Bioengineering/Molecular Biology

MSc with 3–5 years industrial wet-lab experience

Tools

AKTA FPLC

Barcode inventory systems

DNA production workflows

Job description

LabGenius Therapeutics in London is seeking a protein expression lead to drive the gene-to-protein workflow from cloning to large-scale purification, ensuring ultra-pure reagents feed ML models. You will spearhead stable CHO cell line development and troubleshoot complex constructs with a cross-disciplinary team.

You will collaborate with Data Science and wet-lab colleagues to scale production while maintaining rigorous data records and project timelines.