Senior Scientist, PBPK/PBBM Modeling & Simulation

TekWissen UK; Stone Cross; On-site; GBP 75,000 - 110,000; Full time

Benefits offered by this job

Equal opportunity employer

Job summary

TekWissen UK is seeking a Senior Scientist in Biopharmaceutics Modelling & Simulation to drive PBPK/PBBM based decisions across development. You will build and apply mechanistic models of oral absorption and in vivo performance, collaborating with pharmacology, formulation and clinical teams.

PhD or MSc in pharmaceutical sciences or related field is required, with PBPK/PBBM expertise and software experience (Simcyp, GastroPlus, PK-Sim).

Qualifications

• PhD or MSc in pharmaceutical sciences, biopharmaceutics, pharmacokinetics or related field.
• PBPK/PBBM expertise with mechanistic modelling or model-informed development.
• Solid knowledge of oral absorption, dissolution, permeability and PK.
• Experience with Simcyp, GastroPlus or PK-Sim software.
• Strong communication; publications or regulatory contributions valued.

Responsibilities

• Develop, verify and apply PBPK/PBBM models for project needs.
• Assess oral absorption, dissolution and bioavailability scenarios.
• Calibrate models, run sensitivity and uncertainty analyses.
• Collaborate with lab and clinical teams for in vitro–in vivo links.
• Support dissolution method development and regulatory documentation.
• Communicate modelling results in reports and presentations.

Skills

PBPK

PBBM

pharmacometrics

mechanistic modelling

model-informed drug development

oral absorption

dissolution

biopharmaceutics

pharmacokinetics

Simcyp

GastroPlus

PK-Sim

Python

R

MATLAB

AI/ML

Education

PhD in Pharmaceutical Sciences or related

MSc with strong PBPK/PBBM experience

Tools

Simcyp

GastroPlus

PK-Sim

Python

R

MATLAB

Job description

TekWissen UK is seeking a Senior Scientist in Biopharmaceutics Modelling & Simulation to drive PBPK/PBBM based decisions across development. You will build and apply mechanistic models of oral absorption and in vivo performance, collaborating with pharmacology, formulation and clinical teams.

PhD or MSc in pharmaceutical sciences or related field is required, with PBPK/PBBM expertise and software experience (Simcyp, GastroPlus, PK-Sim).