Senior Scientist – Gene Editing (Bioprocessing R&D)

BioLegend, Inc.; Cambridge; Vor Ort; GBP 60.000 - 90.000; Vollzeit

Zusammenfassung

Revvity's Bioprocessing R&D team is seeking a Senior Scientist to execute gene editing projects in mammalian bioproduction cell lines for client work, designing KO and KI strategies and contributing to expressing cell line development.

This hands-on, lab-based role requires independence, rigorous experimental design, and clear communication within project teams to ensure timely delivery of high-quality data and recombinant lines.

Qualifikationen

• MSc with PhD or equivalent in Life Sciences, Biochemical Engineering or related field.
• Hands-on expertise in gene editing with KO and KI in mammalian cell lines.
• Strong molecular biology skills including cloning (Gibson/Golden Gate), PCR, qPCR, ddPCR.

Aufgaben

• Design and execute gene editing strategies for KO and KI in mammalian bioproduction cell lines.
• Independently manage assigned project workstreams and communicate with internal teams.
• Analyse and interpret experimental data, drawing conclusions and proposing next steps.
• Maintain accurate lab records and SOPs.

Kenntnisse

Gene editing in mammalian cells

KO & KI strategy design

Cloning techniques (Gibson, GoldenGate

Data analysis

Independent work

Effective communication

Ausbildung

MSc with PhD or equivalent in Life Sciences/related

Tools

Gibson Assembly

Golden Gate Assembly

qPCR

ddPCR

Jobbeschreibung

Revvity's Bioprocessing department is at the forefront of developing advanced expression platforms to enable the manufacturing of next-generation biotherapeutics. We offer a diverse portfolio of mammalian host cell lines and innovative expression technologies designed for rapid identification of high-expressing recombinant clones. Leveraging extensive expertise in gene editing and cell line engineering, we deliver custom solutions tailored to our clients' unique manufacturing needs, for both protein and viral vector therapeutics.

Job Summary

As a Senior Scientist in the Bioprocessing R&D team, you will be primarily responsible for executing gene editing projects in mammalian bioproduction cell lines on behalf of clients, applying your expertise to design and implement targeted knockout (KO) and knock-in (KI) strategies. Working to defined project timelines and client requirements, you will bring strong technical independence and a delivery-focused mindset to ensure high-quality outcomes.

In addition to gene editing, you may also contribute to cell line development projects supporting the generation of expressing mammalian cell lines, broadening the scope of your impact within the team.

This is a hands-on, lab-based role suited to a scientist who thrives in a client-project environment, is comfortable working independently to deadlines, and brings a rigorous and methodical approach to experimental design and execution.

Key Responsibilities

• Design and execute gene editing strategies for KO and KI applications in mammalian bioproduction cell lines, planning and troubleshooting experiments to deliver high-quality, reproducible outcomes within agreed project timelines.
• Independently manage assigned project workstreams, ensuring timely delivery and maintaining clear communication with internal project teams.
• Analyse and interpret experimental data, drawing well-reasoned conclusions and proposing appropriate next steps.
• Maintain accurate and up-to-date laboratory records, including laboratory notebooks and relevant technical documentation such as SOPs and experimental reports.
• Communicate scientific results clearly and concisely in internal project meetings and written reports.
• Collaborate effectively with colleagues across the Bioprocessing team and wider organisation to support project delivery.
• Where required, contribute to cell line development activities supporting the generation of expressing mammalian cell lines for client projects.

Essential Competencies & Requirements

• MSc with PhD or equivalent experience in a relevant scientific discipline (Life Sciences, Biochemical Engineering, or closely related field).
• Demonstrated, hands-on expertise in gene editing with a strong track record of designing and executing KO and KI strategies in mammalian cell lines.
• Solid molecular biology skills, including proficiency in cloning techniques (e.g., Gibson Assembly, Golden Gate Assembly), PCR, qPCR, and ddPCR.
• Proven ability to work independently, manage priorities effectively, and deliver results within defined project timelines.
• Strong experimental design and data analysis skills
• Highly organised, detail-oriented, and committed to producing reliable, reproducible scientific results.
• Excellent written and verbal communication skills, with the ability to present data clearly to internal stakeholders.
• Collaborative team player with a proactive and solution-focused approach.

Desirable Competencies & Requirements

• Experience in CHO cell line development and/or generation of expressing recombinant cell lines (stable pools and/or clones).
• Prior experience working in a client-facing or service-oriented research environment.
• Experience working in GLP or cGMP environments or a strong quality mindset aligned to regulated processes.