Senior Scientist - Lentiviral Vectors

BioLegend, Inc.; Cambridge; On-site; GBP 50,000 - 80,000; Full time

Job summary

BioLegend, Inc. is looking for a Senior Scientist specializing in lentiviral vectors. This role involves leading research projects, optimizing vector designs, and collaborating with various departments to improve therapeutic applications.

Ideal candidates hold a Ph.D. and have a minimum of 5 years of relevant experience, including expertise in virology and molecular biology. The position is crucial in enhancing our lentiviral vector portfolio and requires a hands-on approach in a lab-based environment.

Qualifications

• Minimum 5 years of documented experience in a relevant scientific discipline.
• Proven track record in designing and optimizing lentiviral vectors.
• Experience in transduction workflows and assay development.

Responsibilities

• Lead independent research projects from design through execution and analysis.
• Drive innovation to enhance lentiviral vector offerings.
• Maintain comprehensive laboratory documentation and develop procedures.

Skills

Virology

Molecular Biology

Biochemistry

Cell Biology

Flow Cytometry

Education

Ph.D. in relevant scientific discipline

Job description

Senior Scientist - Lentiviral Vectors

Revvity's Bioprocessing group pioneer advanced expression platforms that power the manufacturing of next generation biotherapeutics. Our portfolio includes specialized mammalian host cell lines and expression systems, designed to produce viral vector therapeutics of choice. Through our gene editing expertise, we deliver custom cell line engineering services that precisely tailor bioproduction cell lines to meet our clients' specific manufacturing requirements for viral vector therapeutics.

Job Summary

As a Senior Scientist in our R&D team, you will serve as ourlentiviral vectors subject matter expert, spearheading the development of Revvity's lentiviral vector offering including supporting further development of our transduction enhancerLentiBOOST.

You will develop cutting-edge vector systems specifically engineered to improve lentiviral vector tropism and transduction efficiency. This role requiresclose collaboration with the Revvity Gene Delivery groupto ensure seamless integration of vector technologies and optimize delivery strategies across therapeutic applications.

This lab-based role requires hands‑on expertise and deep knowledge of lentiviral vector biology, production and purification, with previous experience in engineering lentiviral vectors for delivery of large and complex cargo, as well as transduction assays and potency assay development and validation.

Key Responsibilities

• Lead independent research projects from design through execution, analysis, and troubleshooting with meticulous attention to detail
• Drive innovation to enhance Revvity's lentiviral vector offering
• Support further development of the LentiBOOST portfolio
• Foster collaborative relationships across Revvity departments (Vectorology and Process Development teams amongst others)
• Maintain comprehensive laboratory documentation and develop standard operating procedures
• Present clear, concise data at both internal and external meetings

Essential Competencies & Requirements

• Ph.D. plus minimum 5 years of documented experience in a relevant scientific discipline (virology, molecular biology, biochemistry, or genetics)
• Proven track record designing and optimizing lentiviral vectors and purification processes, with direct experience in transduction workflows, including assay development and optimization
• Advanced technical skills in molecular biology, cell biology, cell culture, and flow cytometry
• Strong leadership capabilities with ability to drive innovation and scientific excellence
• Exceptional team collaboration skills with strong communication abilities and meticulous attention to detail
• Previous experience in envelope protein engineering and pseudo-typing strategies would be a plus
• Previous experience working in Global and commercial environments would be preferred
• Demonstrated scientific curiosity with a proactive approach to knowledge development