Senior Postdoctoral Research Scientist

University-of-Oxford; Oxford; On-site; GBP 42,000 - 54,000; Full time

Benefits offered by this job

Flexible working arrangements

Job summary

The Nuffield Department of Women’s and Reproductive Health at Oxford invites applications for a Senior Postdoctoral Research Scientist to join the EndoCaRe Centre. You will lead translational research translating genetic discoveries into potential treatments for endometriosis, working with our industrial partner to validate targets in patient-derived tissues.

You will hold a PhD/DPhil and substantial postdoctoral experience, with publications and expertise in genome editing, gene/protein

Qualifications

• PhD/DPhil in cell biology, molecular biology, genetics, reproductive biology or related field.
• Postdoctoral experience with genome editing methodologies.
• Strong publication record with first-author papers.
• Experience with gene and protein expression analysis in primary tissues and tissue culture.
• Ability to plan and manage research projects and budgets; supervisory experience.
• Bioinformatic analysis of genomic or transcriptomic data essential.

Responsibilities

• Lead research activities to validate novel therapeutic targets using patient-derived endometriosis tissues.
• Develop and optimise experimental protocols; investigate disease-relevant cellular processes.
• Collaborate with clinicians, geneticists and computational scientists.
• Contribute to publications and presentations; manage research activities and budgets.
• Provide supervision and guidance to other members of the research team.

Skills

Genome editing

Gene expression analysis

Protein expression analysis

Tissue culture

Bioinformatics

Single-cell sequencing

Organoids

Experimental design

Education

PhD/DPhil in cell biology, molecular biology, genetics, reproductive biology or related discipline

Postdoctoral experience in genome editing methodologies

Tools

Genome editing tools (e.g., CRISPR)

In vitro assays

Primary tissue handling

Organoid culture

Job description

Nuffield Department of Women’s and Reproductive Health, level 3, Women’s Centre, John Radcliffe Hospital, Oxford.

The Nuffield Department of Women’s and Reproductive Health is looking for an experienced and highly motivated Senior Postdoctoral Research Scientist to join the internationally recognised Oxford Endometriosis CaRe Centre (EndoCaRe). You will contribute to an exciting translational research programme, working in collaboration with our industrial partner, Gedeon Richter, to translate human genetic discoveries into potential new treatments for endometriosis. You will lead research activities to validate novel therapeutic targets using patient-derived endometriosis tissues, including gene and protein expression analysis, primary cell culture and genome editing techniques. You will develop and optimise experimental protocols, investigate disease-relevant cellular processes and work closely with clinicians, geneticists and computational scientists. You will also contribute to scientific publications, presentations, manage research activities and budgets, and provide supervision and guidance to other members of the research team.

You will hold a PhD/DPhil in cell biology, molecular biology, genetics, reproductive biology or a related discipline, together with postdoctoral research experience in genome editing methodologies. You will have a strong publication record, including first-author papers in peer-reviewed journals, and experience of gene and protein expression analysis in primary tissues, tissue culture and in vitro functional assays. You will demonstrate the ability to independently plan and manage research projects and budgets, supervise graduate research students and work effectively within a multidisciplinary team. Experience of bioinformatic analysis of genomic or transcriptomic data is also essential. Previous experience of working with primary human tissues, organoids, genetic manipulation of primary cells or single-cell and spatial sequencing data would be advantageous.

Applications for flexible working arrangements are welcomed and will be considered in line with business needs. Please note that occasional out-of-hours working may be required to accommodate the timing of patient tissue collection.

The post is offered on a full-time basis and is fixed term for three years.

For informal enquiries about the role, please contact Dr Jennifer Southcombe at [e-mail].

The closing date for applications is 12.00 noon on 26th November 2026. Interviews are expected to take place on 16th December 2026.