Senior Laboratory Research Scientist

LSIndex; Greater London; On-site; GBP 45,000 - 65,000; Full time

Job summary

The Francis Crick Institute in London is seeking a Senior Lab Research Scientist to support the Gutierrez lab's efforts in developing iPSC‑based models of lung infection and treatment. The role focuses on generating tools and performing cell‑based experiments, with emphasis on culture, differentiation and characterization of iPSCs into lung cells.

You will join a diverse, collaborative team and apply advanced iPSC technologies; experience with CRISPR/Cas9 genome editing is desirable and helpful.

Qualifications

• Substantial experience in human iPSC culture, differentiation and reprogramming.
• Experience in CRISPR/Cas9 genome editing is desirable.
• Deep technical knowledge and hands‑on expertise in culture, characterization and differentiation of human iPSCs into lung cells.

Responsibilities

• iPSC culture and maintenance
• iPSC differentiation and differentiated cell production

Skills

iPSC culture

iPSC differentiation

iPSC reprogramming

CRISPR/Cas9 editing

Job description

The Gutierrez lab is in the research group “Host-pathogen interactions in tuberculosis” and has a long-standing interest in developing novel human induced pluripotent stem cell (iPSC)-based in vitro models of complex disease to study infection and treatment (Pellegrino et al.,2021; Aylan et al., 2023; Bussi et al., 2023). The SLRS position has been created to ensure the successful implementation of projects that aim to develop bioengineered stem cells based cellular systems to better understand lung infection and treatment. Specifically, we are engineering physiologically inspired human lung models combining human (iPSC) technologies with microfluidic devices.

This role is critical to generate tools and perform cell-based experiments, requiring substantial experience in human induced pluripotent stem cell (iPSC) culture, differentiation and reprogramming. Experience in CRISPR/Cas9 genome editing is desirable. You will be part of a diverse and collegial team focused on advancing human iPSC-derived technologies to study infection and treatment. You will provide deep technical knowledge and hands‑on expertise in the culture, characterisation and differentiation of human iPSCs into lung cells.

What you will be doing…

As an SLRS at the Crick, you will:

• iPSC culture and maintenance
• iPSC differentiation and differentiated cell production