Research Associate, Protein Expression & Purification

flagshippioneeringinc; Cambridge; On-site; GBP 42,000 - 56,000; Full time

Job summary

Flagship Labs 109, Inc. is seeking a Research Associate to support recombinant protein production at Fathem, focusing on expression, purification, and characterization of challenging protein targets including membrane proteins for cryo-EM-ready samples.

This hands-on role sits at the intersection of biochemistry, structural biology, and AI-driven technology development, building robust purification workflows and high-throughput assays to feed next-generation computational models.

Qualifications

• Bachelor's degree in Biochemistry or related field, with 2+ years relevant experience in an academic or industry laboratory or a MS degree in Biochemistry or a related field.
• Hands‑on experience in recombinant protein expression and purification, encompassing all steps of the end-to-end workflow: transformation/transfection, and the full range of chromatographic techniques (affinity, ion‑exchange, and size‑exclusion).
• Familiarity with protein construct design and analytical techniques used to assess recombinant protein quality, including size‑exclusion chromatography, dynamic light scattering, and thermostability assays.
• Proven ability to rigorously document their work in an ELN and maintain lab organization and inventories.
• More than one year of experience with recombinant protein production and purification in an industry setting; Proficiency with ÄKTA systems and UNICORN software; Experience implementing protein characterization and binding assays (ELISA, BLI, enzymatic activity).

Responsibilities

• Support recombinant protein production, purification, and characterization.
• Develop robust purification workflows and characterization assays.
• Work at the intersection of protein biochemistry, structural biology, and AI-driven technology development.
• Build robust purification workflows and high-throughput data generation.
• Document experiments meticulously in an ELN and maintain lab inventories.

Skills

Recombinant protein expression

Protein purification

Chromatography techniques

ELN documentation

Lab organization

Education

Bachelor's degree in Biochemistry or related field

MS in Biochemistry or related field

Tools

ÄKTA systems

UNICORN software

Job description

Flagship Labs 109, Inc. is seeking a Research Associate to support recombinant protein production at Fathem, focusing on expression, purification, and characterization of challenging protein targets including membrane proteins for cryo-EM-ready samples.

This hands-on role sits at the intersection of biochemistry, structural biology, and AI-driven technology development, building robust purification workflows and high-throughput assays to feed next-generation computational models.