Protein Expression & Purification Specialist

European Bioinformatics Institute; Hinxton; On-site; GBP 36,000 - 43,000; Full time

Benefits offered by this job

Private medical insurance

Flexible working

Relocation support

Campus facilities

Job summary

EMBL Cambridge area (Hinxton) seeks a Scientific Officer to contribute to the Protein Expression and Purification Core Facility. You will coordinate protein production projects across expression systems and chromatography platforms, delivering rigorous scientific outcomes and supporting teaching activities.

The role requires hands-on experience with recombinant protein expression in E. coli, insect and mammalian cells, and strong knowledge of chromatography (affinity/ion exchange/size

Qualifications

• Undergraduate or postgraduate qualification in molecular biology, biochemistry or related field, or an equivalent combination of education, training and experience.
• Hands-on experience with recombinant protein expression in E. coli, insect cells and mammalian cells, at different scales and throughputs.
• Strong knowledge of protein chromatography techniques, including affinity, ion exchange and size exclusion chromatography and demonstrated experience in applying them.
• Strong technical skills in the advanced use, troubleshooting and maintenance of protein chromatography platforms (ÄKTA, NGC or comparable systems).
• Strong organisational skills and the ability to coordinate multiple projects and priorities in parallel.
• Strong communication and interpersonal skills, a service-oriented approach to users, and fluency in English.

Responsibilities

• Coordinate protein production projects with the facility’s users and team members, from initial project discussion through to delivery and reporting of results.
• Develop appropriate protein production strategies for user projects, including construct design, choice of expression system and purification workflow.
• Deliver high-quality purified proteins to internal and external users through the application of appropriate protein expression and purification methods.
• Develop and optimise high-throughput expression and purification workflows to improve the efficiency and capacity of the facility.
• Maintain chromatography instruments and provide technical support to enable the effective operation of the facility’s protein production workflows.
• Train and support users, visitors and new team members working in the facility, and contribute to practical courses, workshops and other teaching activities.
• Ensure that work in the facility complies with laboratory safety requirements.

Skills

Recombinant protein expression

Protein chromatography

English communication

Project coordination

Team training

Education

Bachelor's or MSc in molecular biology/biochemistry

Equivalent education/experience

Tools

ÄKTA

NGC

Job description

EMBL Cambridge area (Hinxton) seeks a Scientific Officer to contribute to the Protein Expression and Purification Core Facility. You will coordinate protein production projects across expression systems and chromatography platforms, delivering rigorous scientific outcomes and supporting teaching activities.

The role requires hands-on experience with recombinant protein expression in E. coli, insect and mammalian cells, and strong knowledge of chromatography (affinity/ion exchange/size