Nucleoside/Nucleotide Synthesis Chemist for RNA Therapeutics

Eleven Therapeutics; Cambridge; On-site; GBP 55,000 - 85,000; Full time

Job summary

ScionxBio in Cambridge seeks a talented Synthetic Chemist to design and synthesize chemically modified nucleosides and nucleotides, with emphasis on diphosphates and triphosphates for next-generation RNA therapeutics.

You will collaborate across chemistry, RNA biology, formulation and process development teams, applying robust purification and analytical methods to deliver scalable workflows. Recent PhD graduates or MSc with industrial experience are welcome.

Qualifications

• PhD in Organic Chemistry or Medicinal Chemistry (recent graduates welcome)
• Strong background in nucleoside/nucleotide synthesis
• Hands-on experience synthesising nucleoside diphosphates/triphosphates
• Solid chromatography/purification of polar, charged molecules (HPLC)
• Analytical characterization of nucleotides and oligonucleotides
• Strong problem-solving and attention to detail
• Excellent communication and teamwork in interdisciplinary settings

Responsibilities

• Design and synthesise chemically modified nucleosides and nucleotides, focusing on diphosphates/triphosphates
• Develop and optimise routes to mono-, di- and triphosphates and related analogues
• Purify polar, charged nucleotide species using ion-exchange and RP-HPLC
• Characterise products using HPLC, LC-MS, NMR and UV spectroscopy
• Scale synthesis and purification workflows to improve yield and reproducibility
• Troubleshoot synthesis, work-up, purification and analysis challenges
• Support oligonucleotide synthesis and RNA incorporation when needed
• Collaborate with chemistry, RNA biology, formulation and process development teams
• Maintain accurate records of experiments and results

Skills

Nucleoside synthesis

Nucleotide synthesis

Chemical modifications

HPLC purification

Analytical characterization

Problem solving

Team collaboration

Education

PhD in Organic Chemistry or Medicinal Chemistry

MSc with substantial relevant industrial experience

Tools

HPLC

LC-MS

NMR

UV spectroscopy

Job description

ScionxBio in Cambridge seeks a talented Synthetic Chemist to design and synthesize chemically modified nucleosides and nucleotides, with emphasis on diphosphates and triphosphates for next-generation RNA therapeutics.

You will collaborate across chemistry, RNA biology, formulation and process development teams, applying robust purification and analytical methods to deliver scalable workflows. Recent PhD graduates or MSc with industrial experience are welcome.