Senior RNA Therapeutics Design Lead

Grünenthal Group; Maidenhead; Hybrid; GBP 120,000 - 150,000; Full time

Job summary

Grünenthal Group is seeking a senior leader in RNA therapeutics to design and optimize RNA-based medicines. You will integrate RNA biology with oligonucleotide chemistry to advance gene knockdown and RNA regulation, shaping discovery and early development strategies.

The role requires extensive experience in designing RNA therapeutics, strong computational skills (Python/R), and the ability to work across a matrixed team to deliver impactful medicines. Hybrid work in the UK is expected.

Qualifications

• PhD in RNA biology, molecular biology, computational biology, bioinformatics, or related discipline.
• 10+ years of relevant industry experience.
• 5+ years in therapeutic antisense or siRNA design and optimisation.
• Strong computational skills with scripting in Python or R.
• Experience designing siRNA across CNS and systemic delivery contexts.
• Ability to work in a highly matrixed, cross-functional environment.

Responsibilities

• Lead the design and computational optimisation of RNA therapeutics, integrating RNA biology with oligonucleotide chemistry for gene knockdown and RNA regulation.
• Define and prioritise target sites and design strategies by integrating sequence features, RNA accessibility, transcript structure, cross-species alignment, and emerging data.
• Drive design-test-learn cycles by analysing datasets linking sequence, chemistry, and biological activity to inform decisions.
• Develop and apply computational tools and workflows (e.g. Python or R) for scalable oligonucleotide design and data integration.
• Partner with oligonucleotide chemists and delivery scientists to co-optimise sequence, chemical modifications, and delivery for potency and tissue activity.
• Lead discovery programs advancing RNA therapeutic candidates toward profiling and clinical development.

Skills

Computational biology

RNA biology

Biotech industry experience

Education

PhD in RNA biology, molecular biology, computational biology, bioinformatics, or related discipline

Tools

Python

R

Job description

Grünenthal Group is seeking a senior leader in RNA therapeutics to design and optimize RNA-based medicines. You will integrate RNA biology with oligonucleotide chemistry to advance gene knockdown and RNA regulation, shaping discovery and early development strategies.

The role requires extensive experience in designing RNA therapeutics, strong computational skills (Python/R), and the ability to work across a matrixed team to deliver impactful medicines. Hybrid work in the UK is expected.