Method Development Lead

Nexus Life Sciences; Woking; On-site; GBP 54,000 - 66,000; Full time

Benefits offered by this job

Leadership opportunity in a cutting-ed

Professional development and training

Supportive, collaborative work culture

Job summary

Nexus Life Sciences is seeking an MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. This role combines technical expertise with team leadership.

You will lead method development, optimise extraction/LC methods, mentor the team, and ensure GLP/SOP compliance while supporting regulatory submissions and CAPAs. A strong background in HPLC/UPLC/LCMSMS is essential.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimise analytical extraction techniques, chromatography methods, and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure compliance with GLP, SOPs, and international guidelines.
• Troubleshoot analytical methods and recommend improvements.
• Oversee cost-effective laboratory operations and consumable spend.
• Write and approve Methods of Analysis and transferring validated methods to analytical teams.
• Support regulatory submissions and resolve regulatory queries.
• Conduct investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Skills

GxP laboratory management

HPLC

UPLC

LCMSMS

Chromatography data systems

Method development & validation

Troubleshooting

Regulatory compliance

Leadership

DOE experience

Education

Bachelor's degree in Biochemistry/Biomedical Science

Tools

Empower

MassLynx

Minitab

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.