Method Development Lead

Nexus Life Sciences; Plymouth; On-site; GBP 50,000 - 60,000; Full time

Job summary

Nexus Life Sciences in Plymouth, UK, is seeking an MS Method Development Lead to drive development and validation of LCMSMS bioanalytical methods under GxP standards. This role blends technical excellence with team leadership.

You will optimise extraction and chromatography, mentor the Method Development & Validation team, ensure GLP compliance, support regulatory submissions, and lead continuous improvement in a cutting-edge bioanalytical lab.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory with at least 2+ years in management.
• Proven expertise in HPLC/UPLC and LCMSMS method development and validation.
• Strong knowledge of GLP, SOPs, and regulatory requirements.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimise extraction, chromatography, and LC methods.
• Manage and mentor the Method Development & Validation team.
• Ensure GLP compliance and adherence to SOPs.
• Support regulatory submissions and respond to queries.
• Drive continuous improvement and CAPA processes.
• Prepare, review, and transfer validated methods to analytical teams.

Skills

GxP laboratory experience

HPLC

UPLC

LCMSMS

Chromatography data systems

Method development & validation

Problem solving

Regulatory and GLP knowledge

Leadership and mentoring

Education

Degree in Biochemistry, Biomedical Science, or related field

Tools

Empower

MassLynx

Minitab

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.