Method Development Lead

Nexus Life Sciences; Aberdeen City; On-site; GBP 54,000 - 66,000; Full time

Benefits offered by this job

Competitive salary

Job summary

Nexus Life Sciences in the United Kingdom seeks an experienced MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. This role combines technical expertise with strategic leadership to guide a dedicated team.

You will lead method development, optimise extraction and chromatography, and ensure GLP compliance while supporting regulatory submissions and continuous improvement initiatives.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory with 2+ years in management.
• Experience with HPLC/UPLC/LCMSMS and chromatography data systems.
• Strong problem-solving, communication, and leadership skills.

Responsibilities

• Lead method development and validation as SME.
• Optimize extraction, chromatography, and LC columns.
• Manage and mentor the MD&V team.
• Ensure GLP compliance and regulatory readiness.
• Draft and transfer validated methods to teams.
• Support regulatory submissions and audits.
• Drive CAPA and continuous improvement.
• Lead team meetings and staff development sessions.

Skills

Method development

Validation

Leadership

GxP knowledge

Troubleshooting

Regulatory knowledge

Communication

Organization

Education

Bachelor's degree in Biochemistry or related field

Tools

Empower

MassLynx

Minitab

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.