Method Development Lead

Nexus Life Sciences; Cambridge; On-site; GBP 50,000 - 60,000; Full time

Benefits offered by this job

Leadership growth

Professional development

Collaborative culture

Job summary

Nexus Life Sciences in Cambridge seeks a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. You will combine technical expertise with team leadership to deliver robust, compliant methods.

The role involves guiding method development, optimization of extraction and chromatography, mentoring the team, and supporting regulatory submissions in a cutting-edge lab environment.

Qualifications

• Degree in biochemistry or life sciences required.
• Experience in a GxP laboratory with leadership responsibilities.
• Strong knowledge of HPLC/UPLC/LCMSMS and validation.

Responsibilities

• Lead method development and validation as a SME.
• Optimize extraction techniques and chromatography.
• Manage and mentor the Method Development & Validation team.
• Ensure GLP, SOPs, and international guidelines compliance.
• Troubleshoot analytical methods and implement improvements.
• Oversee cost-effective lab operations and consumables spend.
• Write and approve Methods of Analysis and transfer methods.
• Support regulatory submissions and address regulatory queries.
• Conduct investigations, CAPAs, and drive continuous improvement.
• Lead team meetings and staff development sessions.

Skills

HPLC

UPLC

LCMSMS

Method development

Validation

Leadership

Problem solving

Communication

Regulatory compliance

GxP knowledge

Education

Degree in Biochemistry, Biomedical Science, or related field

Tools

Empower

Mass Lynx

DOE

Minitab

SPE

Liquid-Liquid extraction

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.