Lead LCMS/MS Method Development & Validation (GxP)

Nexus Life Sciences; England; On-site; GBP 54,000 - 66,000; Full time

Benefits offered by this job

Leadership opportunity in a cutting-ed

Professional development and training

Supportive, collaborative culture

Opportunity to contribute to bioanalyt

Job summary

Nexus Life Sciences is seeking a highly skilled MS Method Development Lead in the United Kingdom to drive development and validation of LCMSMS bioanalytical methods under GxP standards.

The role combines technical leadership with team management, overseeing a dedicated Method Development & Validation group and supporting regulatory submissions. A degree in Biochemistry or related field is required, with 4+ years in a GxP lab and 2+ years in management.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Responsibilities

• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Skills

GxP leadership

Method development

Troubleshooting

Regulatory knowledge

Leadership

Communication

Documentation

Education

Bachelor's degree in Biochemistry or related field

Tools

LCMS/MS

HPLC/UPLC

Empower

MassLynx

Minitab

Job description

Nexus Life Sciences is seeking a highly skilled MS Method Development Lead in the United Kingdom to drive development and validation of LCMSMS bioanalytical methods under GxP standards.

The role combines technical leadership with team management, overseeing a dedicated Method Development & Validation group and supporting regulatory submissions. A degree in Biochemistry or related field is required, with 4+ years in a GxP lab and 2+ years in management.