Lead LC-MS Method Development & Validation (GxP)

Nexus Life Sciences

Stockport

On-site

GBP 54,000 - 66,000

Full time

5 days ago

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Benefits offered by this job

Leadership opportunity

Professional development

Training opportunities

Job summary

Nexus Life Sciences is seeking an MS Method Development Lead in the UK to drive development and validation of LCMSMS bioanalytical methods under GxP standards. The role combines technical expertise with team leadership.

Responsibilities include leading method development/validation, overseeing the MDV team, ensuring GLP/SOP compliance, and supporting regulatory submissions. Strong LCMSMS experience and leadership skills are essential.

Qualifications

4+ years in a GxP laboratory with at least 2 years in management.
Expertise in HPLC, UPLC, LCMSMS and chromatography data systems.
Proficiency in method development, optimisation and validation.
Strong problem-solving and troubleshooting capabilities.
Knowledge of protein precipitation, SPE and Liquid-Liquid extraction techniques.
Understanding of regulatory and GLP requirements.
Strong communication, organisational and leadership skills.

Responsibilities

Leading method development and validation as a subject matter expert.
Optimising analytical extraction techniques, chromatography methods, and LC columns.
Managing and mentoring the Method Development & Validation team.
Ensuring compliance with GLP, SOPs, and international guidelines.
Troubleshooting analytical methods and recommending improvements.
Overseeing cost-effective laboratory operations and consumable spend.
Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
Supporting regulatory submissions and resolving regulatory queries.
Conducting investigations, implementing CAPAs, and driving continuous improvement.
Preparing, reviewing, and ensuring adherence to GLP SOPs.
Leading team meetings and staff development sessions.