Lead LCMSMS Method Development in a GxP Lab

Nexus Life Sciences; Wakefield; On-site; GBP 45,000 - 60,000; Full time

Benefits offered by this job

Professional development

Job summary

Nexus Life Sciences in Wakefield is seeking an accomplished MS Method Development Lead to drive the development and validation of LC-MS/MS bioanalytical methods under GxP standards.

You will lead a dedicated Method Development & Validation team, optimise extraction and chromatography methods, ensure GLP compliance, support regulatory submissions, and coach staff toward continuous improvement.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory with 2+ years in management.
• Expertise in HPLC/UPLC/LC-MS/MS and chromatography data systems.
• Strong problem-solving and regulatory knowledge.

Responsibilities

• Lead method development and validation as SME for LC-MS/MS methods.
• Optimise analytical extraction techniques, chromatographic methods, and LC columns.
• Mentor and manage the Method Development & Validation team.
• Ensure GLP, SOPs and international guidelines compliance.
• Troubleshoot assays and recommend improvements.
• Support regulatory submissions and respond to inquiries.
• Drive CAPAs and continuous improvement initiatives.
• Prepare, review and ensure adherence to GLP SOPs.

Skills

GxP lab management

LC-MS/MS

HPLC/UPLC

Method development & validation

Troubleshooting

Sample prep techniques

GLP/regulatory knowledge

Leadership & communication

Design of Experiments (DOE)

Education

Bachelor’s degree in Biochemistry, Biomedical Science, or related field

Tools

Empower

MassLynx

Minitab

GC experience

Job description

Nexus Life Sciences in Wakefield is seeking an accomplished MS Method Development Lead to drive the development and validation of LC-MS/MS bioanalytical methods under GxP standards.

You will lead a dedicated Method Development & Validation team, optimise extraction and chromatography methods, ensure GLP compliance, support regulatory submissions, and coach staff toward continuous improvement.