Lead Director, Clinical Pharmacology & MIDD Strategy

Moderna; Oxford; Presencial; GBP 100.000 - 150.000; Tempo integral

Benefícios oferecidos por esta vaga

Healthcare benefits

Well-being resources

Family benefits

Paid time off

Global recharge days

Year-end shutdown

Retirement savings options

Resumo da vaga

Moderna in the UK (Harwell/Oxford area) is seeking a senior Clinical Pharmacology expert to shape model-informed development and integrate nonclinical and clinical data across oncology, immunology, and rare disease programs. You will build quantitative strategies, map dose selections, and influence regulatory strategies in a highly collaborative setting.

The role emphasizes PK/PD modeling, exposure–response analyses, and translating data into actionable development decisions while partnering

Qualificações

• PhD in Clinical Pharmacology, Pharmacometrics, Pharmaceutics, Statistics, Engineering, or a related field.
• Minimum of 5 years of industry experience in clinical pharmacology/DMPK/Pharmacometrics.
• Experience in oncology is strongly preferred; immune therapeutics and/or rare diseases a plus.
• Experience integrating nonclinical and clinical evidence to support first-in-human predictions, dose selection, and regulatory decisions.
• Proficiency with data analysis and modeling software (R, Phoenix WinNonlin, NONMEM, Monolix) and clear result communication.

Responsabilidades

• Develop fit-for-purpose clinical pharmacology plans defining quantitative strategies across development lifecycles.
• Independently perform and evaluate quantitative analyses, translating findings into dose selection and regimen optimization.
• Integrate diverse program data to build a coherent quantitative evidence base for development decisions.
• Collaborate with cross-functional teams to apply modeling and simulation to predict human PK/PD and inform study design.
• Partner with Pharmacometrics and QSP to align modeling needs with program decisions.

Conhecimentos

Quantitative pharmacology

DMPK

Pharmacometrics

PK/PD modeling

MIDD (Model-Informed Drug Development)

Data analysis & visualization

Cross-functional collaboration

Regulatory documentation

Communication skills

Independent contributor

Formação

PhD in Clinical Pharmacology or related field

Ferramentas

R

Phoenix WinNonlin

NONMEM

Monolix

Descrição da vaga

Moderna in the UK (Harwell/Oxford area) is seeking a senior Clinical Pharmacology expert to shape model-informed development and integrate nonclinical and clinical data across oncology, immunology, and rare disease programs. You will build quantitative strategies, map dose selections, and influence regulatory strategies in a highly collaborative setting.

The role emphasizes PK/PD modeling, exposure–response analyses, and translating data into actionable development decisions while partnering