Lead, Clinical Pharmacology & Quantitative Modeling

Moderna Therapeutics Inc.; Oxford; Híbrido; GBP 120.000 - 170.000; Tempo integral

Benefícios oferecidos por esta vaga

Healthcare benefits

Generous paid time off

Family building benefits

Resumo da vaga

Moderna Therapeutics Inc. is seeking an Associate Director, Clinical Pharmacology in Oxford, UK, to lead quantitative strategies across oncology, immunology, and rare diseases.

The role emphasizes model-informed drug development, cross-functional teamwork, and regulatory collaboration to optimize dose selection and study design. You will integrate nonclinical and clinical data, develop robust PK/PD analyses, and guide first-in-human decisions while contributing to the progression of Moderna’s

Qualificações

• PhD in Clinical Pharmacology, Pharmacometrics, Pharmaceutics, Statistics, Engineering, or related field with 5+ years in industry.
• Strong quantitative pharmacology background incl. PK/PD, modeling & simulation.
• Experience integrating nonclinical and clinical evidence for FIH predictions and regulatory decisions.

Responsabilidades

• Develop quantitative, fit-for-purpose Clinical Pharmacology plans across programs.
• Perform/critically evaluate PK/PD analyses and exposure–response modeling.
• Integrate nonclinical, translational, and clinical data to support development decisions.
• Collaborate on modeling needs with Pharmacometrics/QSP to guide dose selection & trial design.
• Contribute to regulatory documentation and interactions with authorities.

Conhecimentos

PK/PD modeling

Exposure– response analysis

Modeling & simulation

Translational PK/PD

Data analysis & visualization

Formação

PhD in Clinical Pharmacology or related field

Ferramentas

R

Phoenix WinNonlin

NONMEM

Monolix

Descrição da vaga

Moderna Therapeutics Inc. is seeking an Associate Director, Clinical Pharmacology in Oxford, UK, to lead quantitative strategies across oncology, immunology, and rare diseases.

The role emphasizes model-informed drug development, cross-functional teamwork, and regulatory collaboration to optimize dose selection and study design. You will integrate nonclinical and clinical data, develop robust PK/PD analyses, and guide first-in-human decisions while contributing to the progression of Moderna’s