Director, Clinical Pharmacology & Modelling

Lindus Health; Greater London; Hybrid; GBP 140,000 - 210,000; Full time

Job summary

Relation is seeking a Director Clinical Pharmacology to lead quantitative pharmacology across discovery and development. You will drive Model‑Informed Drug Development (MIDD) strategies, integrate nonclinical and clinical PK/PD, and optimize trial design across modalities in a hybrid London setting.

You will oversee PK/PD modelling, liaise with Translational Safety and Biomarkers teams, and mentor teams while advancing AI-enabled decision tools.

Qualifications

• PhD/PharmD/MD with specialisation in DMPK, Pharmacometrics, in vivo/Clinical Pharmacology, or related field.
• Significant experience in quantitative clinical pharmacology across development stages.
• Strong understanding of drug discovery and translational development; experience with MIDD.
• Proven ability to translate quantitative data into strategic decisions for development programs.

Responsibilities

• Lead clinical pharmacology input into study design across IND enabling and Phase 1 trials, with progression to Phase 2/3.
• Oversee PK/PD modelling and simulations from non-clinical to clinical data.
• Collaborate across Translational Safety, Translational Pharmacology and Biomarkers to improve predictive accuracy.
• Coordinate external CRO partnerships and regulatory interactions with a clear program strategy.
• Embed AI-enabled approaches into workflows to enhance decision-making.

Skills

Quantitative Clinical Pharmacology

MIDD principles

Data analytics

Communication skills

Education

PhD/PharmD/MD in DMPK or related

Tools

NONMEM

R

Monolix

WinNonlin

GastroPlus

SimCyp

Job description

Relation is seeking a Director Clinical Pharmacology to lead quantitative pharmacology across discovery and development. You will drive Model‑Informed Drug Development (MIDD) strategies, integrate nonclinical and clinical PK/PD, and optimize trial design across modalities in a hybrid London setting.

You will oversee PK/PD modelling, liaise with Translational Safety and Biomarkers teams, and mentor teams while advancing AI-enabled decision tools.