Kidney Genomics: Functional Genomics Research Associate

Imperial College London; Greater London; On-site; GBP 38,000 - 48,000; Full time

Benefits offered by this job

41 days off a year

Generous pension schemes

Job summary

Imperial College London is recruiting a postdoctoral Research Associate in Functional Genomics for the Renal Genomics group. Based at the MRC Laboratory of Medical Sciences (Hammersmith Campus), the role investigates how gene-regulatory networks drive kidney and urinary tract development and CAKUT.

You will establish iPSC-derived kidney organoids, apply CRISPR interference to perturb regulatory elements, and profile outcomes using single-nucleus multiomics, CUT&RUN and low-input chromosome

Qualifications

• PhD (or equivalent) in stem cell biology, developmental biology, genetics or molecular biology.
• Experience with mammalian cell culture and molecular biology.
• Strong interest in kidney development and disease.
• Training in both wet and dry lab approaches including single-cell multiomic analyses.

Responsibilities

• Establish and run iPSC-derived kidney and ureteric bud organoid models.
• Use CRISPR interference to perturb candidate regulatory elements.
• Profile consequences using single-nucleus multiomics, CUT&RUN and low-input chromatin techniques.
• Collaborate with bioinformaticians and clinicians to test mechanistic hypotheses.
• Publish results in peer‑reviewed journals and present at conferences.

Skills

Mammalian cell culture

Molecular biology

Genetics/genomics

Stem cell biology

Collaboration with bioinformaticians

Education

PhD (or equivalent) in biology or related field

Tools

CRISPR interference

CUT&RUN

Single-nucleus multiomics

Low-input chromosome conformation capture

Job description

Imperial College London is recruiting a postdoctoral Research Associate in Functional Genomics for the Renal Genomics group. Based at the MRC Laboratory of Medical Sciences (Hammersmith Campus), the role investigates how gene-regulatory networks drive kidney and urinary tract development and CAKUT.

You will establish iPSC-derived kidney organoids, apply CRISPR interference to perturb regulatory elements, and profile outcomes using single-nucleus multiomics, CUT&RUN and low-input chromosome