Research Associate in Functional Genomics

SONICOM; Greater London; On-site; GBP 38,000 - 48,000; Full time

Benefits offered by this job

Wet and dry lab training

Independent research ideas supported

Collaborative, diverse team culture

Job summary

Imperial College London invites applications for a postdoctoral Research Associate in Functional Genomics to join the Renal Genomics group. The role focuses on iPSC-derived kidney organoids, CRISPR perturbations, and multiomics profiling to understand kidney development and CAKUT.

You will collaborate with bioinformaticians and clinicians, publish advances in high-quality journals, and have opportunities to pursue independent ideas within the lab's core aims at Imperial's Hammersmith campus.

Qualifications

• PhD (or equivalent) in biology (stem cell/development/genomics/molecular biology).
• Experience with mammalian cell culture and molecular biology techniques.
• Interest in kidney development and disease biology.

Responsibilities

• Establish and run iPSC-derived kidney and ureteric bud organoid models.
• Use CRISPR interference to perturb candidate regulatory elements.
• Profile consequences with single-nucleus multiomics, CUT&RUN and low-input chromosome conformation capture.
• Collaborate with bioinformaticians and clinicians to test mechanistic hypotheses.
• Publish in peer-reviewed journals and present at conferences.
• Develop independent research ideas within the lab's focus.

Skills

Mammalian cell culture

Molecular biology skills

Stem cell biology

Developmental biology

Genomics / genetics

Education

PhD or equivalent in biology

Job description

Research Associate in Functional Genomics

We are looking to appoint a highly motivated postdoctoral Research Associate in Functional Genomics to join our newly established Renal Genomics research group. Funded by the Medical Research Council and Kidney Research UK, this exciting post will investigate how gene-regulatory networks drive kidney and urinary tract development, and how disruption of these mechanisms lead to congenital anomalies of the kidneys and urinary tract (CAKUT) – the commonest cause of kidney failure in children.

What you would be doing

You will establish and run iPSC-derived kidney and ureteric bud organoid models, use CRISPR interference to perturb candidate cis-regulatory elements, and profile the consequences using single-nucleus multiomics, CUT&RUN and low-input chromosome conformation capture techniques. You will be based at the MRC Laboratory of Medical Sciences; a discovery research institute located at Imperial College London (Hammersmith Campus) and will have the opportunity to undertake advanced training in stem cells and kidney organoid models. You will take the initiative in driving your project forward, working collaboratively with bioinformaticians and clinicians to generate and experimentally test mechanistic hypotheses. You will submit publications to high-quality peer-reviewed journals, present your work at national and international conferences, and will be encouraged to develop independent research ideas within the lab's core focus.

What we are looking for

• A PhD (or equivalent experience) in a relevant biology field – e.g. stem cell or developmental biology, genetics/genomics, or molecular biology.
• Experience of mammalian cell culture and strong molecular biology skills.
• A strong interest in understanding the drivers of kidney development and disease.

What we can offer you

• This role offers excellent training in both wet and dry lab approaches including the generation and analysis of single-cell multiomic datasets.
• You will work at a world-leading Institution and be part of a diverse team interacting with leading experts.
• You will have an opportunity to make discoveries about human health that have an impact on patients.
• An opportunity to develop your own research interests within a research group focussed on kidney development and disease.
• Sector-leading salary and remuneration package (including 41 days off a year and generous pension schemes).
• Be part of a diverse, inclusive and collaborative work culture with various staff networks and resources to support your personal and professional wellbeing .

Further information

This is a full time, fixed term role for 3 years. The expected start date is around 1 st November 2026.

If you require any further details about the role, please contact: Dr Melanie Chan ([e-mail]).

Attached documents are available under links. Clicking a document link will initialize its download.

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities mentioned above.

We reserve the right to close the advert before the stated closing date, should we receive a high volume of applications. It is therefore advisable that you submit your application as early as possible to avoid disappointment.

If you encounter any technical issues while applying online, please don't hesitate to email us at [e-mail]. We're here to help.

About Imperial

Welcome to Imperial, a global top-ten university where scientific imagination leads to world-changing impact.

Join us and be part of something bigger. From global health to climate change, AI to business leadership, here at Imperial we navigate some of the world’s toughest challenges. Whatever your role, your contribution will have a lasting impact.

As a member of our vibrant community of 22,000 students and 8,000 staff, you’ll collaborate with passionate minds across nine London campuses and a global network.

This is your chance to help shape the future. We hope you’ll join us at Imperial College London.

Our Culture

We work towards equality of opportunity, to eliminating discrimination, and to creating an inclusive working environment for all. We encourage applications from all backgrounds, communities and industries, and are committed to employing a team that has diverse skills, experiences and abilities. You can read more about our commitment on our web pages .

Proud signatory of the Armed Forces Covenant. We welcome applications from the Armed Forces community.

Our values are at the root of everything we do, and everyone in our community is expected to demonstrate respect, collaboration, excellence, integrity, and innovation.