Head of Structural Biology: Protein Dynamics & Cryo-EM

Placements24; Greater London; Hybrid; GBP 80,000 - 134,000; Full time

Benefits offered by this job

Relocation assistance

Health benefits

Retirement benefits

Performance incentives

State-of-the-art facilities

Job summary

Premier Biomedical Research Institute is seeking a Lead Structural Biologist to direct the Protein Dynamics Group in East London, Eastern Cape, ZA. You will lead a team focused on high-resolution structures and protein dynamics using X-ray crystallography and cryo-EM, with a strong emphasis on drug discovery and collaboration.

The role requires a Ph.D. in structural biology and a minimum of 10 years of post-doctoral experience, along with a proven track record in leadership, publications, and

Qualifications

• Ph.D. in Structural Biology, Biochemistry, Biophysics, or a related field.
• Minimum of 10 years of post-doctoral experience in structural biology with a proven leadership track record.
• Extensive hands-on experience in X-ray crystallography and/or cryo-EM.
• Proven ability to solve complex protein structures.
• Strong understanding of protein biochemistry, molecular biology, and enzymology.
• Experience with protein expression, purification, and biophysical characterization methods.
• Proven leadership and project management skills.
• Excellent communication, presentation, and interpersonal skills.
• Strong publication record in high-impact journals.

Responsibilities

• Lead and manage a team of structural biologists and research associates.
• Direct efforts to determine high-resolution structures of therapeutically relevant proteins.
• Oversee application and advancement of X-ray crystallography and cryo-EM techniques.
• Characterize dynamic properties and conformational changes of proteins.
• Integrate structural data with functional and biochemical assays.
• Develop and implement novel approaches for protein expression, purification, and crystallization.
• Collaborate with computational biologists and medicinal chemists to guide drug discovery.
• Publish findings in leading journals and present at international meetings.
• Secure research funding through grants and external collaborations.
• Mentor junior scientists and foster an innovative research environment.

Skills

Leadership

Project management

Communication skills

Team mentoring

Education

Ph.D. in Structural Biology or related field

Tools

X-ray crystallography

Cryo-EM

Job description

Premier Biomedical Research Institute is seeking a Lead Structural Biologist to direct the Protein Dynamics Group in East London, Eastern Cape, ZA. You will lead a team focused on high-resolution structures and protein dynamics using X-ray crystallography and cryo-EM, with a strong emphasis on drug discovery and collaboration.

The role requires a Ph.D. in structural biology and a minimum of 10 years of post-doctoral experience, along with a proven track record in leadership, publications, and