Postdoc Lead: Cryo-EM & Cytoskeletal Remodeling

Instruct-ERIC; Greater London; On-site; GBP 38,000 - 46,000; Full time

Job summary

The Francis Crick Institute in the United Kingdom invites applications for a Postdoctoral Fellow in Structural Biology and Cytoskeletal Remodeling. The Crick is Europe’s largest biomedical research institute, fostering collaboration and cutting-edge science.

The successful candidate will use cryo-EM and biochemistry to study microtubule remodeling starting January 2027. You will develop and lead the project, produce and characterize proteins, and apply cryo-EM with computational analysis to

Qualifications

• PhD or PhD in the final stages of submission in structural biology, biochemistry, molecular biology, biophysics, or a related discipline.
• Experimental expertise in protein biochemistry and cryo-EM, including sample preparation and data collection.
• Strong interest in combining these approaches with quantitative fluorescence microscopy.
• Experience designing experiments, applying appropriate statistical analysis, critically interpreting data and troubleshooting research problems.
• Evidence of scientific initiative and the ability to develop and pursue research questions independently.
• Evidence of communicating research clearly through scientific writing and presentations.
• A collaborative approach to research and the ability to work effectively with colleagues.
• Experience in single-particle image processing and model building. (Desirable)

Responsibilities

• Developing and leading a research project investigating the molecular mechanisms of cytoskeletal remodeling
• Producing and characterizing recombinant proteins and protein complexes, and establishing assays to measure their interactions and activity
• Using cryo-EM and computational image analysis to investigate the organisation and conformational states of molecular assemblies
• Integrating structural findings with biochemical and fluorescence microscopy experiments to test mechanistic hypotheses
• Analysing and documenting experiments rigorously, presenting findings at scientific meetings, and contributing to manuscripts and publications.

Skills

Cryo-EM

Single-particle analysis

Protein biochemistry

Fluorescence microscopy

Computational image analysis

Independent researcher

Education

PhD in structural biology

PhD in biophysics

Tools

Relion

CryoSPARC

Phenix

Job description

The Francis Crick Institute in the United Kingdom invites applications for a Postdoctoral Fellow in Structural Biology and Cytoskeletal Remodeling. The Crick is Europe’s largest biomedical research institute, fostering collaboration and cutting-edge science.

The successful candidate will use cryo-EM and biochemistry to study microtubule remodeling starting January 2027. You will develop and lead the project, produce and characterize proteins, and apply cryo-EM with computational analysis to