Senior Structural Biologist – Drug Discovery Leader

Placements24; Greater London; On-site; GBP 120,000 - 180,000; Full time

Benefits offered by this job

Health coverage

Retirement plan

Paid time off

Conference attendance

Job summary

Placements24 is recruiting a Senior Structural Biology Researcher for a leading biopharmaceutical company, based at a campus in East London. The role focuses on applying advanced structural biology techniques to elucidate molecular mechanisms of disease targets and guide the design of novel therapeutics.

You will lead projects using X-ray crystallography, cryo-EM, and NMR, determine high‑resolution structures, and mentor junior scientists while collaborating with chemists and biologists to

Qualifications

• Ph.D. in Structural Biology, Biochemistry, Biophysics, or a related field.
• 7+ years post‑doctoral experience in structural biology with focus on protein structure determination.
• Hands-on experience with X-ray crystallography, cryo-EM, or NMR.
• Ability to solve complex protein structures and interpret them biologically.
• Experience with protein expression and purification techniques.

Responsibilities

• Lead structural biology projects using X-ray crystallography, cryo-EM, and NMR.
• Determine high-resolution structures of protein targets and complexes.
• Characterize protein dynamics and conformational changes relevant to function.
• Collaborate with medicinal chemists, biologists, and pharmacologists to integrate data.
• Develop and optimize protocols for protein expression, purification, and crystallization.
• Analyze structural data and prepare reports and presentations.
• Contribute to design of small molecules and biologics based on insights.

Skills

Analytical skills

Problem-solving

Leadership

Mentoring

Education

Ph.D. in Structural Biology

Tools

PyMOL

Chimera

Job description

Placements24 is recruiting a Senior Structural Biology Researcher for a leading biopharmaceutical company, based at a campus in East London. The role focuses on applying advanced structural biology techniques to elucidate molecular mechanisms of disease targets and guide the design of novel therapeutics.

You will lead projects using X-ray crystallography, cryo-EM, and NMR, determine high‑resolution structures, and mentor junior scientists while collaborating with chemists and biologists to