Postdoc: Structural Biology (Cryo-EM & Membrane Complexes)

Imperial Enterprise; Greater London; On-site; GBP 51,000 - 59,000; Full time

Job summary

Imperial College London is recruiting a structural biologist to lead a research project on bacterial secretion systems, focusing on membrane protein complexes with cryo-EM and single-molecule fluorescence techniques.

You will guide the project from cloning to purification and structure determination, using advanced imaging and biophysical methods. An internationally competitive salary is offered, with Wellcome Trust support and career development opportunities.

Qualifications

• PhD in structural biology with cryo-EM, X-ray or NMR experience.
• Experience designing workflows for protein structure determination from cloning to data processing.
• Cryo-EM workflows including sample prep, data collection and processing are essential.
• Light microscopy experience is desirable and at least one first-author publication is expected.

Responsibilities

• Lead a project from cloning through purification, structure determination and mechanistic dissection.
• Work on challenging multi-component membrane complexes in-cell.
• Apply cryo-EM (SPA, in-situ SPA, tomography) and TIRF with single-molecule FRET to study dynamics.

Skills

Cryo-EM workflows

Protein purification

Molecular cloning & mutagenesis

Single-molecule FRET

Light microscopy

Education

PhD in structural biology (cryo-EM/X-ray/NMR)

Tools

Cryo-EM

TIRF microscopy

X-ray crystallography

NMR

Job description

Imperial College London is recruiting a structural biologist to lead a research project on bacterial secretion systems, focusing on membrane protein complexes with cryo-EM and single-molecule fluorescence techniques.

You will guide the project from cloning to purification and structure determination, using advanced imaging and biophysical methods. An internationally competitive salary is offered, with Wellcome Trust support and career development opportunities.