Senior Structural Biology Researcher

Placements24; Greater London; Vor Ort; GBP 120.000 - 180.000; Vollzeit

Benefits dieser Stelle

Health coverage

Retirement plan

Paid time off

Conference attendance

Zusammenfassung

Placements24 is recruiting a Senior Structural Biology Researcher for a leading biopharmaceutical company, based at a campus in East London. The role focuses on applying advanced structural biology techniques to elucidate molecular mechanisms of disease targets and guide the design of novel therapeutics.

You will lead projects using X-ray crystallography, cryo-EM, and NMR, determine high‑resolution structures, and mentor junior scientists while collaborating with chemists and biologists to

Qualifikationen

• Ph.D. in Structural Biology, Biochemistry, Biophysics, or a related field.
• 7+ years post‑doctoral experience in structural biology with focus on protein structure determination.
• Hands-on experience with X-ray crystallography, cryo-EM, or NMR.
• Ability to solve complex protein structures and interpret them biologically.
• Experience with protein expression and purification techniques.

Aufgaben

• Lead structural biology projects using X-ray crystallography, cryo-EM, and NMR.
• Determine high-resolution structures of protein targets and complexes.
• Characterize protein dynamics and conformational changes relevant to function.
• Collaborate with medicinal chemists, biologists, and pharmacologists to integrate data.
• Develop and optimize protocols for protein expression, purification, and crystallization.
• Analyze structural data and prepare reports and presentations.
• Contribute to design of small molecules and biologics based on insights.

Kenntnisse

Analytical skills

Problem-solving

Leadership

Mentoring

Ausbildung

Ph.D. in Structural Biology

Tools

PyMOL

Chimera

Jobbeschreibung

About the Role

Our client, a leading biopharmaceutical research company, is seeking a highly accomplished Senior Structural Biology Researcher to join their drug discovery and development team. This pivotal role involves applying state-of-the-art structural biology techniques to elucidate the molecular mechanisms of disease targets and to guide the design of novel therapeutics. You will be based at our advanced research campus in East London, Eastern Cape, ZA, working in a collaborative and innovative environment. This is a hands-on, on-site position, essential for utilizing our sophisticated instrumentation and engaging directly with experimental work. If you possess deep expertise in protein structure determination and a passion for translating structural insights into therapeutic strategies, we invite you to contribute to our mission of developing life-changing medicines.

Key Responsibilities

• Lead structural biology projects, employing techniques such as X-ray crystallography, cryo-EM, and NMR spectroscopy.
• Determine high-resolution structures of protein targets and their complexes with drug candidates.
• Characterize protein dynamics and conformational changes relevant to biological function.
• Collaborate closely with medicinal chemists, biologists, and pharmacologists to integrate structural data into drug design campaigns.
• Develop and optimize protocols for protein expression, purification, and crystallization/sample preparation.
• Analyze and interpret structural data, preparing comprehensive reports and presentations.
• Contribute to the design of small molecules and biologics based on structural insights.
• Stay abreast of the latest advancements and emerging technologies in structural biology.
• Mentor junior scientists and contribute to the scientific leadership of the structural biology group.

Requirements

• Ph.D. in Structural Biology, Biochemistry, Biophysics, or a related field.
• A minimum of 7 years of post-doctoral research experience in structural biology, with a strong focus on protein structure determination.
• Extensive hands-on experience with at least one major structural biology technique (X-ray crystallography, cryo-EM, or NMR).
• Proven ability to solve complex protein structures and interpret them in a biological context.
• Experience with protein expression and purification techniques.
• Strong understanding of molecular biology, biochemistry, and drug discovery processes.
• Excellent analytical, problem-solving, and critical thinking skills.
• Proficiency in structural analysis software and visualization tools.
• Excellent written and verbal communication skills, with a record of publication in peer-reviewed journals.
• Experience leading research projects and mentoring junior scientists is highly desirable.

Benefits

Our client offers a highly competitive salary, performance-based bonuses, and a comprehensive benefits package including excellent health coverage, retirement savings plans, and generous paid time off. You will have access to state-of-the-art structural biology facilities and the opportunity to work on impactful projects at the forefront of pharmaceutical innovation. We provide ample opportunities for professional development, including attendance at leading scientific conferences. Join our collaborative team in East London and contribute to the discovery of new medicines.