Computational Protein Design Research Assistant

University of Bristol; England; On-site; GBP 25,000 - 32,000; Full time

Job summary

The University of Bristol invites applications for a Research Support Assistant within the PIONEER programme. You will work at the interface of computational biology and protein engineering, applying AI-based design tools and structure prediction to advance research objectives.

You will contribute to data generation and analysis, collaborate with researchers across disciplines, and gain experience with high-performance computing and publishing research findings.

Qualifications

• Degree in a relevant scientific discipline.
• Experience with computational protein design methods.
• Experience with protein structure prediction tools (AF3, Boltz-2).
• Strong written and verbal communication skills.
• Ability to work independently with guidance when needed.
• Good organisational and workload management skills.
• Collaborative and multidisciplinary teamwork experience.

Responsibilities

• Design protein and peptide binders using AI-based design tools and computational methods.
• Develop and optimise computational design pipelines on HPC clusters.
• Perform molecular dynamics simulations to evaluate protein structures and interactions.
• Collaborate with software engineers and operate on UK’s Isambard-AI system.
• Collaborate with lab researchers to characterise designed proteins and peptides.
• Analyse and present research findings at team meetings and contribute to publications.
• Maintain accurate records and contribute to reporting and milestones.
• Occasionally train students or colleagues in computational methodologies.

Skills

Computational protein design

Data analysis

Communication skills

Education

Bachelor's degree in a relevant scientific discipline

Tools

AF3

ESMFold2

Boltz-2

Job description

The University of Bristol invites applications for a Research Support Assistant within the PIONEER programme. You will work at the interface of computational biology and protein engineering, applying AI-based design tools and structure prediction to advance research objectives.

You will contribute to data generation and analysis, collaborate with researchers across disciplines, and gain experience with high-performance computing and publishing research findings.