Computational Structural Biologist

Bindbridge; Cambridge; Remote; GBP 65,000 - 110,000; Full time

Job summary

Bindbridge is seeking a Computational Structural Biologist to join an remote, UK-focused team building AI-driven molecular glue discovery for sustainable agriculture. You will lead computational studies of protein structures, develop scalable data pipelines and reusable software, and collaborate with experimentalists and engineers to translate findings into actionable insights.

Applicants should have a strong background in structural biology, experience with computational methods on proteins,

Qualifications

• Postgraduate degree or equivalent experience in computational structural biology.
• Experience using computational methods to study protein structures or complexes.
• Strong programming and software engineering for scientific software.
• Experience building data pipelines and working with databases.
• Ability to define research questions and draw defensible conclusions.
• Experience interpreting data from structural/biophysical methods.
• Excellent written and verbal communication; ability to lead research across disciplines.

Responsibilities

• Lead computational studies of protein structures, complexes and molecular glue-induced interactions using methods such as structure prediction, co-folding, docking, molecular dynamics and integrative modelling.
• Work with experimental scientists and advisers to incorporate structural and biophysical evidence into models, understand its limitations and identify useful follow-up experiments.
• Write, test and maintain reusable scientific software for structural modelling, analysis and evaluation, contributing directly to shared codebases and working with AI and software engineers to integrate, deploy and scale it.
• Design and build data pipelines that ingest, validate, harmonise and version structural, sequence, experimental and computational data.
• Develop and maintain data models and databases that connect proteins, structures, experiments, predictions and results, with clear quality controls, metadata and provenance.
• Design benchmarks and evaluations that show where computational approaches work, where they fail and how confidently their results can be used.
• Document methods, assumptions, limitations and results, then communicate their scientific implications across disciplines.

Skills

Computational structural biology

Protein structure understanding

Programming

Data pipelines

Documentation

Team collaboration

Education

Postgraduate degree in computational biology

Tools

Python

Linux

Git

Job description

Compensation: Competitive, based on experience

Computational Structural Biologist

Type: Full-time

Location: Remote (UK time ± 2 hours; UK preferred)

Compensation: Competitive, based on experience

About us

• Bindbridge is advancing sustainable agriculture through AI-powered molecular glue discovery and design.
• Backed by Speedinvest and Nucleus Capital, we are building a computational platform to bring targeted protein degradation to agriculture.
• Our first goal is to discover herbicides that revolutionise crop protection while minimising environmental impact.

Key responsibilities

• Lead computational studies of protein structures, complexes and molecular glue-induced interactions using methods such as structure prediction, co-folding, docking, molecular dynamics and integrative modelling.
• Work with experimental scientists and advisers to incorporate structural and biophysical evidence into models, understand its limitations and identify useful follow-up experiments.
• Write, test and maintain reusable scientific software for structural modelling, analysis and evaluation, contributing directly to shared codebases and working with AI and software engineers to integrate, deploy and scale it.
• Design and build data pipelines that ingest, validate, harmonise and version structural, sequence, experimental and computational data.
• Develop and maintain data models and databases that connect proteins, structures, experiments, predictions and results, with clear quality controls, metadata and provenance.
• Design benchmarks and evaluations that show where computational approaches work, where they fail and how confidently their results can be used.
• Document methods, assumptions, limitations and results, then communicate their scientific implications across disciplines.

What you will bring

• A strong foundation in computational structural biology, structural bioinformatics or a closely related field, including an understanding of protein structure, interactions and conformational behaviour, gained through postgraduate study or equivalent professional experience.
• Experience using computational methods to investigate protein structures or complexes and drawing conclusions from the results.
• Strong programming and software engineering skills with experience developing tested, maintainable scientific software.
• Experience building data pipelines and working with databases or structured scientific data systems, including validation, metadata, provenance and versioning.
• The ability to define a research question, select an appropriate computational approach and draw defensible conclusions from incomplete or uncertain evidence.
• Experience interpreting data from at least one structural or biophysical method, together with the ability to learn unfamiliar methods with support from specialists and advisers.
• Clear written and verbal communication, together with the independence to lead complex research while collaborating across scientific and technical disciplines.
  

Nice to have

• Experience with molecular glues, targeted protein degradation, induced proximity or other protein-protein interaction problems.
• Experience combining multiple sources of sparse or uncertain evidence through integrative structural modelling.
• Familiarity with machine-learning approaches to protein structure prediction, complex modelling or molecular design.
• Experience running scientific workflows across large datasets or shared computing infrastructure.
• Experience in biotechnology, drug discovery, E3 ligase biology, chemoproteomics or plant biology.
• Experience using AI-assisted development tools while validating their outputs and applying scientific judgement.

Why join us

• Apply computational structural biology to difficult and underexplored problems in molecular glue discovery.
• Shape the scientific methods, software and data foundations behind an emerging discovery platform.
• Collaborate closely with scientists, AI researchers, software engineers and experienced external advisers.
• Join an early team where your work can influence how computational structural biology is practised and developed.
• Meet colleagues in person through company and team meetups when useful, usually in London.
• Receive support for relevant conferences, publications and patents.