Research Support Assistant

University of Bristol; West of England; On-site; GBP 26,000 - 38,000; Full time

Job summary

The University of Bristol invites applications for a Research Support Assistant to join the multi-institutional PIONEER programme in the School of Biochemistry and Biomedical Sciences. You will work with Prof. Ross Anderson, Prof.

Mark Szczelkun and a collaboration of researchers, focusing on computational biology and protein engineering. This role is ideal for a recent graduate or early-career researcher seeking training in AI-based design tools, structure prediction, and high-performance

Qualifications

• Degree in a relevant scientific discipline with enthusiasm for a research career in computational biology or protein engineering.
• Experience with computational protein design methods and data analysis.
• Experience with protein structure prediction tools such as AF3 and Boltz-2.

Responsibilities

• Design protein and peptide binders using computational methods and AI-based design tools.
• Use structure prediction platforms on HPC clusters to develop design pipelines.
• Perform molecular dynamics simulations to evaluate protein structures.
• Collaborate with researchers and software engineers to support project development on Isambard-AI.
• Collaborate with laboratory researchers to experimentally characterise designed proteins and peptides.
• Analyse and present findings at meetings and contribute to publications.
• Maintain accurate research records and contribute to reporting and milestones.
• Support and train students or colleagues in computational methodologies.

Skills

Computational protein design

Data analysis

High-performance computing

Education

Bachelor's degree in a relevant scientific discipline

Tools

AF3

Boltz-2

ESMFold2

RFDiffusion3

proteinMPNN

DiffDock

Job description

An exciting opportunity has arisen for a Research Support Assistant to join the multi-institutional PIONEER (Programmable In-Organellar Nucleic-acid Entry, Expression and Retention) programme, funded through the ARIA Precision Mitochondria scheme. The project brings together experts across disciplines to develop innovative approaches for engineering biological systems and organelles.

Based in the School of Biochemistry and Biomedical Sciences, you will work closely with Prof. Ross Anderson, Prof. Mark Szczelkun, and a collaborative team of researchers. This position is ideal for a recent graduate or early-career researcher looking to build expertise at the interface of computational protein design and engineering biology. The role is designed to provide training, mentorship and research experience that will support future progression to Research Associate positions.

What will you be doing?

You will contribute to the delivery of key research objectives within the PIONEER programme by applying computational approaches to protein and peptide design and supporting the generation and analysis of research data. Key responsibilities include:

• Designing protein and peptide binders using state-of-the-art computational methods and AI-based design tools, including RFDiffusion3, proteinMPNN, Boltzgen and DiffDock.
• Using structure prediction platforms such as AF3, ESMFold2 and Boltz-2 on high performance computing clusters to develop and optimise computational design pipelines.
• Performing molecular dynamics simulations to evaluate protein structures and interactions.
• Working with research software engineers and specialist computational platforms to support project development on the UK’s most powerful supercomputer, Isambard-AI.
• Collaborating with laboratory-based researchers to experimentally characterise designed proteins and peptides.
• Analysing and presenting research findings at team meetings and contributing to scientific publications.
• Maintaining accurate research records and contributing to project reporting and milestone delivery.
• Supporting and occasionally training students or colleagues in computational methodologies.

You should apply if

• You have a degree in a relevant scientific discipline and are enthusiastic about developing a research career in computational biology, protein engineering or related fields. We are looking for candidates who can demonstrate:
• Experience with computational protein design methods and associated data analysis.
• Experience of protein structure prediction tools such as AF3 and Boltz-2.
• Strong written and verbal communication skills, including the ability to present scientific findings clearly.
• The ability to work independently while recognising when to seek guidance.
• Good organisational skills and the ability to manage workloads effectively.
• A collaborative approach and enthusiasm for working within a multidisciplinary research team.
• Experience of high-performance computing, gene editing systems, bacterial defence systems, or research laboratory environments would be advantageous but is not essential.

This is an outstanding opportunity to contribute to a high-profile, cutting-edge research programme while developing valuable computational and research skills in a supportive and ambitious environment.

Additional information

Contract type: Fixed Term Contract (Specialist Skills)

Work pattern: Full time / 35 hours per week

Grade: H

School/Unit: School of Biochemistry and Biomedical Sciences

This advert will close at 23:59 UK time on Monday 2nd November 2026

Shortlisting will take place on Tuesday 3rd November 2026

Interviews will take place on Tuesday 10th November 2026

For informal queries please contact: Ross Anderson ( Professor of Biological Chemistry) - [e-mail] / 0117 455 8937

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