Analytical Scientist - LCMS

TieTalent; Oxford; On-site; GBP 40,000 - 65,000; Full time

Job summary

An innovative analytics team is seeking an LC-MS Associate Scientist to drive the development of next-generation monoclonal antibody therapeutics. This role involves developing and optimizing LC-MS methods, supporting key characterization of therapeutic monoclonal antibodies, and integrating with upstream development teams. If you have a passion for advancing biologics and a strong background in LC-MS analysis, this is an exciting opportunity to contribute to impactful projects in a forward-thinking environment. Join a dynamic team where your expertise will make a difference in the world of biologics.

Qualifications

• 3+ years of hands-on experience in LC-MS analysis of biologics.
• Strong understanding of assay development and CQA analysis.

Responsibilities

• Develop and optimise LC-MS assays for mAb characterisation.
• Set up and maintain a routine LC-MS service, including team training.
• Troubleshoot instrumentation and ensure data quality.

Skills

LC-MS analysis

Assay development

Problem-solving skills

Documentation skills

Education

BSc in Biochemistry

MSc in Molecular Biology

MSc in Analytical Chemistry

Tools

Waters BioAccord

Benchling

Job description

We're hiring for an LC-MS Associate Scientist to join an innovative analytics team driving the development of next-generation monoclonal antibody therapeutics. If you have experience with LC-MS and a passion for advancing biologics, this could be a great opportunity to apply your skills in a forward-thinking environment.

The Role:

You’ll develop and optimise LC-MS methods (e.g., intact mass and N-released glycosylation analysis) and help establish a robust routine analytical service. Your work will support key characterisation of therapeutic monoclonal antibodies and integrate closely with upstream development teams.

Key Responsibilities:

Develop and optimise LC-MS assays for mAb characterisation

Set up and maintain a routine LC-MS service, including team training

Troubleshoot instrumentation and ensure data quality

Standardise analysis templates compatible with ELNs and ML integration

Collaborate across scientific teams to ensure alignment

Contribute to SOPs, lab upkeep, and internal presentations

What We're Looking For:

BSc or MSc in Biochemistry, Molecular Biology, Analytical Chemistry, or similar

3+ years’ hands-on experience in LC-MS analysis of biologics

Strong understanding of assay development and CQA analysis

Excellent documentation and problem-solving skills

Bonus Skills:

Experience with Waters BioAccord and Benchling

Exposure to high-throughput pipelines and broader mAb analytics (e.g., ELISA, qPCR)

Familiarity with ICH guidelines and QbD principles

Location: Oxford

Interested in learning more?

If you have strong LC-MS experience and want to work on impactful biologics projects, we’d love to hear from you. Apply now to explore the next step in your scientific career