Analytical Scientist - LCMS

ZipRecruiter; Oxford; On-site; GBP 35,000 - 55,000; Full time

Job summary

An innovative analytics team is seeking an LC-MS Associate Scientist to advance the development of next-generation monoclonal antibody therapeutics. This role involves developing and optimizing LC-MS methods, supporting key characterization of therapeutic monoclonal antibodies, and collaborating with upstream development teams. If you have a passion for biologics and possess strong LC-MS experience, this is a fantastic opportunity to work in a forward-thinking environment and contribute to impactful projects. Join a dynamic team where your expertise will drive scientific advancements and help shape the future of therapeutics.

Qualifications

• 3+ years of hands-on experience in LC-MS analysis of biologics.
• Strong understanding of assay development and CQA analysis.

Responsibilities

• Develop and optimise LC-MS assays for mAb characterisation.
• Set up and maintain a routine LC-MS service, including team training.
• Collaborate across scientific teams to ensure alignment.

Skills

LC-MS analysis

assay development

problem-solving skills

documentation skills

Education

BSc in Biochemistry

MSc in Molecular Biology

MSc in Analytical Chemistry

Tools

Waters BioAccord

Benchling

Job description

Job Description

We're hiring for an LC-MS Associate Scientist to join an innovative analytics team driving the development of next-generation monoclonal antibody therapeutics. If you have experience with LC-MS and a passion for advancing biologics, this could be a great opportunity to apply your skills in a forward-thinking environment.

The Role:

You’ll develop and optimise LC-MS methods (e.g., intact mass and N-released glycosylation analysis) and help establish a robust routine analytical service. Your work will support key characterisation of therapeutic monoclonal antibodies and integrate closely with upstream development teams.

Key Responsibilities:

1. Develop and optimise LC-MS assays for mAb characterisation.
2. Set up and maintain a routine LC-MS service, including team training.
3. Troubleshoot instrumentation and ensure data quality.
4. Standardise analysis templates compatible with ELNs and ML integration.
5. Collaborate across scientific teams to ensure alignment.
6. Maintain detailed, GLP-compliant experimental records.
7. Contribute to SOPs, lab upkeep, and internal presentations.

What We're Looking For:

1. BSc or MSc in Biochemistry, Molecular Biology, Analytical Chemistry, or similar.
2. 3+ years’ hands-on experience in LC-MS analysis of biologics.
3. Strong understanding of assay development and CQA analysis.
4. Excellent documentation and problem-solving skills.

Bonus Skills:

1. Experience with Waters BioAccord and Benchling.
2. Exposure to high-throughput pipelines and broader mAb analytics (e.g., ELISA, qPCR).
3. Familiarity with ICH guidelines and QbD principles.

Location:

Oxford

Salary:

Competitive + benefits

Interested in learning more? If you have strong LC-MS experience and want to work on impactful biologics projects, we’d love to hear from you.

Apply now to explore the next step in your scientific career.