Scientist Analytical Development - Oxford

Immunocore; Oxford; On-site; GBP 40,000 - 70,000; Full time

Job summary

An innovative biotechnology firm is seeking a Scientist for Analytical Development to join its dynamic team in Oxford. This role involves characterizing biotherapeutic molecules using advanced protein characterization and mass spectrometry techniques. The ideal candidate will have a strong background in analytical development, particularly with HPLC and LC-MS methods. The company values collaboration and innovation, providing a supportive environment for scientific advancement. If you're passionate about improving patient outcomes through cutting-edge therapies, this opportunity is perfect for you.

Qualifications

• 2+ years in recombinant protein or antibody analytical development.
• Experience in HPLC and LC-MS methods development.

Responsibilities

• Characterize biotherapeutic T-cell receptor molecules using mass spectrometry.
• Support impurity characterization and process development.

Skills

HPLC methods development

LC-MS method development

Protein characterization

Analytical development

Laboratory procedures

Troubleshooting

GMP principles

Education

BSc or MSc in biochemistry

PhD in a related discipline

Tools

Mass spectrometry

Electrophoretic chromatography

Job description

Scientist Analytical Development - Oxford

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company dedicated to developing transformative medicines for oncology, infectious diseases, and autoimmune diseases. Our R&D leaders are recognized as some of the industry's most successful drug developers, fostering an environment of innovation and collaboration.

We focus on delivering first-in-class biological therapies using our innovative soluble TCR platform. Our ImmTAX molecules enable a new generation of precision drugs that harness the immune system to treat diseases with high unmet medical needs. We value our employees as our greatest asset and promote an inclusive workplace embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE).

We are committed to developing breakthrough therapies that improve patients' lives and advancing medicine. Immunocore is an equal opportunity employer, encouraging applications from individuals of all backgrounds.

Job Purpose

To characterize our biotherapeutic recombinant T-cell receptor molecules using protein characterization and mass spectrometry methods, and to contribute to the development of characterization methods for our biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass spectrometry analysis.

Key Responsibilities

1. Support drug substance and drug product impurity characterization and identification.
2. Perform protein sequence and post-translational modification identification, including glycosylation analysis.
3. Support process development by analyzing process intermediates.
4. Develop characterization methods for ImmTAX and other products.
5. Contribute to writing study protocols and reports.
6. Plan experiments, meet deadlines, and advise on risks and deviations.
7. Expand scientific knowledge through learning and mentoring.
8. Maintain accurate laboratory records and use equipment effectively.
9. Communicate research findings to colleagues and management.
10. Adhere to safe working practices according to EHS policies.

Person Specification

Essential Experience & Knowledge

• Background in recombinant protein or antibody analytical development or QC with ≥2 years industry experience.
• Experience in HPLC methods development for recombinant proteins or antibodies.
• Experience in LC-MS method development.
• Proficiency in laboratory procedures, buffer and reagent design, troubleshooting, and electrophoretic chromatographic mass spectrometry.
• Understanding of assay qualification/validation and GMP principles.

Desirable

• Knowledge of stability studies and glycosylation analysis.
• Experience in method transfer and external collaborations.
• Conference presentations and analytical support for clinical trial materials.

Education & Qualifications

• Essential: BSc or MSc in biochemistry, biotechnology, or related field.
• Desirable: PhD in a related discipline.