Postdoc: Tumor Mechanobiology & Colorectal Cancer

Biopractify; France; Hybrid; EUR 42,000 - 54,000; Full time

Job summary

The Institut Gustave Roussy invites applications for a Postdoctoral Researcher in Tumor Mechanobiology and Colorectal Cancer. The role focuses on mechanical signals and cancer cell plasticity, combining quantitative imaging, spatial transcriptomics, and tissue mechanics in organoid and tumor models.

The successful candidate will work at biology–physics interface, with access to patient-derived organoids and clinical samples, under ERC Starting Grant funding for two years, extendable.

Qualifications

• Expertise in computational and/or quantitative biology.
• Strong interest in interdisciplinary cancer research.
• Ability to work across wet-lab and dry-lab approaches.
• Ability to work in a multidisciplinary research environment.

Responsibilities

• Investigate how mechanical signals within tumors influence cancer cell states and progression.
• Develop and apply quantitative imaging approaches for cellular and tissue-level changes.
• Bridge tissue mechanics and transcriptomics to understand plasticity in organoids and tumors.
• Collaborate across biology, physics and quantitative research teams.

Skills

Computational biology

Quantitative biology

Interdisciplinary research

Multidisciplinary teamwork

Tools

Spatial transcriptomics

Single-cell sequencing

Traction force microscopy

Quantitative imaging

Image analysis

Cell segmentation

Cell tracking

Morphometry

Job description

🧬 Postdoctoral Researcher – Tumor Mechanobiology & Colorectal Cancer | Institut Gustave Roussy

Institution: Institut Gustave Roussy

Research Group: Tumor Dynamics and Plasticity Group

🔬 Research Area: Tumor Mechanobiology | Colorectal Cancer | Quantitative Imaging | Spatial Transcriptomics | Tissue Mechanics | Cancer Biology | Tumor Plasticity

The Tumor Dynamics and Plasticity Group at Institut Gustave Roussy, led by Carlos Pérez-González and supported by an ERC Starting Grant, is seeking a motivated Postdoctoral Researcher to investigate the mechanical evolution of colorectal cancer.

The project aims to understand how mechanical and biochemical signals influence cancer cell plasticity, combining tumor mechanobiology, quantitative imaging, spatial transcriptomics, and tissue mechanics.

🔬 What You’ll Work On

Investigate how mechanical signals within tumors influence cancer cell states, plasticity, and colorectal cancer progression.

Develop and apply quantitative imaging approaches to study cellular and tissue-level changes, including:

• Cell tracking
• Cell morphometry
• Quantitative image analysis
• Traction force microscopy

Integrate molecular profiling approaches to investigate the spatial and cellular organization of tumors, including:

• Spatial transcriptomics
• Transcriptomic analysis

Bridge tissue mechanics and transcriptomics to understand how mechanical signals guide cancer cell plasticity in organoids and tumors.

The successful candidate will work at the interface of biology, physics, and quantitative research, using approaches such as:

• Quantitative imaging
• Image analysis
• Cell tracking
• Cell morphometry
• Traction force microscopy
• Spatial transcriptomics
• Tissue mechanics
• Transcriptomics

The project offers an opportunity to combine dry-lab computational approaches with experimental cancer biology.

The research group is part of a newly established multidisciplinary team working at the biology–physics interface.

The successful researcher will have access to:

• Patient-derived organoids
• Clinical cancer samples
• Imaging approaches
• Quantitative and computational tools

Wet-lab experience in imaging, organoid culture, and immunostaining is not required but will be considered an asset.

Applicants should have:

• Expertise in computational and/or quantitative biology.
• Strong interest in interdisciplinary cancer research.
• Interest in working across both wet-lab and dry-lab approaches.
• Ability to work in a multidisciplinary research environment.
• Interest in tumor mechanics, quantitative imaging, or cancer cell plasticity.

Experience in the following areas would be advantageous:

• Image analysis
• Computational biology
• Quantitative biology
• Imaging
• Organoid culture
• Spatial transcriptomics
• Tissue mechanics

🌟 What You’ll Gain

• Research experience in tumor mechanobiology.
• Opportunity to study the mechanical evolution of colorectal cancer.
• Advanced experience in quantitative imaging.
• Exposure to cell segmentation, tracking, and morphometry.
• Experience with spatial transcriptomics and single-cell sequencing.
• Opportunity to integrate tissue mechanics with transcriptomic data.
• Experience working with patient-derived organoids and clinical samples.
• Interdisciplinary research experience at the biology–physics interface.
• Opportunity to work within a newly established multidisciplinary research team.

The Tumor Dynamics and Plasticity Group investigates how physical and molecular signals shape tumor cell states and cancer progression.

The group combines tumor mechanobiology, quantitative imaging, tissue mechanics, and transcriptomics to understand cancer cell plasticity.

Located at Institut Gustave Roussy, one of Europe’s largest cancer hospitals, the research environment provides access to clinically relevant samples and patient-derived models.

Position: Postdoctoral Researcher

Institution: Institut Gustave Roussy

Research Group: Tumor Dynamics and Plasticity Group

Funding: ERC Starting Grant

Duration: 2 Years, Extendable

Research Focus: Tumor Mechanobiology | Colorectal Cancer | Cancer Cell Plasticity

Key Areas: Quantitative Biology | Quantitative Imaging | Tissue Mechanics | Transcriptomics

Advanced Approaches: Spatial Transcriptomics | Single-Cell Sequencing | Traction Force Microscopy

Experimental Models: Patient-Derived Organoids | Tumors | Clinical Samples

Wet-Lab Experience: Not Required, but an Asset

The project focuses on understanding how mechanical signals guide cancer cell plasticity during colorectal cancer progression.

Research Group: Tumor Dynamics and Plasticity Group

Position: Postdoctoral Researcher

Funding: ERC Starting Grant

Contract Duration: 2 Years, Extendable

Research Area: Tumor Mechanobiology | Colorectal Cancer | Tumor Plasticity

Research Areas: Quantitative Biology | Cancer Biology | Tissue Mechanics | Transcriptomics

Key Technologies: Quantitative Imaging | Image Analysis | Cell Segmentation | Cell Tracking | Morphometry | Traction Force Microscopy

Molecular Approaches: Spatial Transcriptomics | Single-Cell Sequencing

Experimental Resources: Patient-Derived Organoids | Clinical Samples

Candidate Profile: Computational Biology | Quantitative Biology | Related Fields

Wet-Lab Experience: Not Required, but an Asset

Application Mode: Email

Application Materials: Motivation Letter | CV | Reference Contacts

Postdoctoral Position | Postdoc France | Cancer Research | Colorectal Cancer | Tumor Mechanobiology | Quantitative Biology | Tumor Plasticity | Paris Research Jobs

#Postdoc #PostdoctoralPosition #PostdocFrance #GustaveRoussy #CancerResearch #ColorectalCancer #TumorMechanobiology #CancerBiology

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