Postdoc: Species-Specific tRNA & Cortical Development

Inserm France; Strasbourg; Hybride; EUR 36 000 - 48 000; Plein temps

Résumé du poste

Inserm France in Strasbourg invites a postdoctoral researcher to join the IGBMC team led by Dr. Juliette Godin to study species-specific ADAT functions in cortical development using human iPSC- and mouse ESC-derived models.

The 30-month position advances translational control research with 2D/3D neural systems. The candidate will generate iPSC-derived 2D cortical neural cells and 3D organoids carrying pathogenic variants, analyze phenotypes with immunofluorescence, EdU labeling, and functional

Qualifications

• PhD in a relevant field with recent attainment.
• Experience with human iPSC culture is required.
• Proficiency in standard molecular and cell biology techniques.
• Familiarity with high-throughput sequencing is a plus.

Responsabilités

• Generate and characterize human iPSC-derived 2D cortical neural cells, neurons and 3D cortical organoids carrying pathogenic variants.
• Assess cellular phenotypes (proliferation, cell cycle, identity, maturation) using immunofluorescence and EdU labeling.
• Apply MEA and calcium imaging to study functional maturation.
• Analyze mim-tRNA-seq and ribosome profiling data to define translational programs.
• Present findings at meetings and contribute to manuscript writing; supervise students.

Connaissances

iPSC culture

2D/3D neural differentiation

Immunofluorescence

EdU labeling

MEA & calcium imaging

RNA-seq

Ribosome profiling

Translational control

English communication

Formation

PhD in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or related field

Description du poste

Inserm France in Strasbourg invites a postdoctoral researcher to join the IGBMC team led by Dr. Juliette Godin to study species-specific ADAT functions in cortical development using human iPSC- and mouse ESC-derived models.

The 30-month position advances translational control research with 2D/3D neural systems. The candidate will generate iPSC-derived 2D cortical neural cells and 3D organoids carrying pathogenic variants, analyze phenotypes with immunofluorescence, EdU labeling, and functional