Postdoc: Neural Development in iPSC-Derived Organoids

Inserm France; Illkirch-Graffenstaden; Sur place; EUR 36 000 - 47 000; Plein temps

Résumé du poste

Inserm France, at IGBMC Strasbourg, seeks a postdoctoral researcher to study species-specific ADAT tRNA deaminase functions in cortical development using human iPSC- and mouse ESC-derived models, including 2D neural cells and 3D organoids carrying pathogenic variants.

The project runs for 30 months under Dr. Juliette Godin and collaboration with a bioinformatician, with opportunities for manuscript authorship and supervision of students.

Qualifications

• Ph.D in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or a related field, recently obtained.
• Experience with human iPSC culture and/or 2D/3D neural differentiation protocols is required.
• Proficiency in standard molecular and cell biology techniques (immunofluorescence, Western blot, qPCR, imaging).
• Familiarity with high-throughput sequencing approaches (RNA-seq, ribosome profiling) is a plus.
• Interest in neurodevelopment, neurodevelopmental disorders and translational control.
• Strong written and oral English communication, teamwork and adaptability.

Responsabilités

• Study species-specific ADAT functions in progenitors and neurons.
• Characterize tRNA and translational programs using sequencing data.
• Generate and analyze human iPSC-derived 2D/3D cortical models.
• Present findings at meetings and contribute to manuscripts and reporting.

Connaissances

Human iPSC culture

2D/3D neural differentiation

Molecular biology techniques

English communication

Immunofluorescence & imaging

RNA-seq & ribosome profiling awareness

Formation

Ph.D in Cell Biology / Molecular Biology / Developmental Biology / Neuroscience

Outils

Immunofluorescence

Western blot

qPCR

EdU/pulse-chase labeling

MEA & calcium imaging

RNA-seq data analysis

Description du poste

Inserm France, at IGBMC Strasbourg, seeks a postdoctoral researcher to study species-specific ADAT tRNA deaminase functions in cortical development using human iPSC- and mouse ESC-derived models, including 2D neural cells and 3D organoids carrying pathogenic variants.

The project runs for 30 months under Dr. Juliette Godin and collaboration with a bioinformatician, with opportunities for manuscript authorship and supervision of students.