Postdoctoral Researcher – Species-Specific ADAT Function in Cortical Development

CERBM; France; Sur place; EUR 36 000 - 48 000; Plein temps

Résumé du poste

CERBM's Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Strasbourg, France, seeks a highly motivated postdoctoral researcher to join the project on Physiological and Pathological Mechanisms of Cortical Development. You will study ADAT2/ADAT3 dysfunction using human iPSC- and mouse ESC-derived models in 2D and 3D neural systems.

The 30-month position involves generating and characterizing iPSC-derived cortical cells and organoids carrying pathogenic variants, analyzing

Qualifications

• Ph.D in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or related field, recently obtained.
• Experience with human iPSC culture and neural differentiation protocols is required.
• Proficiency in standard molecular and cell biology techniques (immunofluorescence, western blot, qPCR, imaging).
• Familiarity with high-throughput sequencing approaches (RNA-seq, ribosome profiling) is a plus.
• Interest in neurodevelopment and translational control; strong communication and collaboration skills.

Responsabilités

• Present research findings at team and consortium meetings and at national/international conferences.
• Contribute to manuscript writing and to project reporting; supervise students when applicable.
• Collaborate closely with a bioinformatician to interpret data and contribute to project progress.

Connaissances

Human iPSC culture

2D/3D neural differentiation

Molecular & cell biology techniques

RNA-seq / ribosome profiling analysis

English communication

Interdisciplinary collaboration

Critical thinking

Formation

PhD in Biological sciences

Outils

Immunofluorescence

EdU/pulse-chase labeling

MEA

Calcium imaging

Western blot

qPCR

Description du poste

Organisation/Company CERBM Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 30 Nov 2026 - 00:00 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Other EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

We are looking for a highly motivated postdoctoral researcher to join the "Physiological and Pathological Mechanisms of Cortical Development" team led by Dr. Juliette Godin at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Strasbourg, France. The Godin lab is a recognized expert in translational control during cortical development. The selected candidate will work under the direct supervision of Dr. Efil Bayam (CRCN Inserm), in the framework of the ANR-funded project SpeaDAT, which investigates the species-specific mechanisms of ADAT tRNA deaminase complex dysfunction in brain development. The postdoctoral researcher will study species-specific ADAT functions in progenitors and neurons and characterize impact of ADAT dysfunction on tRNAs and translational programs using human iPSC- and mouse ESCs -derived models, including 2D cortical neural stem cells/neurons and 3D cortical organoids carrying ADAT2 and ADAT3 pathogenic variants. This 30-month position is well suited to a recently graduated PhD experienced with human iPSC culture and/or 2D/3D neural differentiation protocols.

The candidate will generate and characterize human iPSC-derived 2D cortical neural stem cells, neurons and 3D cortical organoids carrying ADAT2 and ADAT3 pathogenic variants, assess cellular phenotypes (proliferation, cell cycle dynamics, progenitor identity, neuronal maturation and synaptic integration) using immunofluorescence, EdU/pulse-chase labeling and functional assays (MEA, calcium imaging) and analyze and interpret human mim-tRNA-seq and ribosome profiling data to characterize species-specific tRNA and translational programs in close collaboration with a bioinformatician.

Present research findings at team and consortium meetings and at national/international conferences, contribute to manuscript writing and to project reporting; contribute to the supervision of students.

Requirements

Research Field Biological sciences Education Level PhD or equivalent

Skills/Qualifications

• Ph.D in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or a related field, recently obtained.
• Experience with human iPSC culture and/or 2D/3D neural differentiation protocols is required.
• Proficiency in standard molecular and cell biology techniques (immunofluorescence, western blot, qPCR, imaging)
• Familiarity with high-throughput sequencing approaches (RNA-seq, ribosome profiling) is a plus
• Interest in neurodevelopment, neurodevelopmental disorders and translational control
• Fast learner, critical thinking, positive attitude, strong problem-solving skills and adaptability to new data and questions
• Good interpersonal skills and ability to work within an interdisciplinary, international consortium
• Strong written and oral communication skills in English
• Strong organizational skills, personal motivation and creativity