Postdoc_species-specific adat function in cortical development_061_jg - h/f

Inserm France; Illkirch-Graffenstaden; Sur place; EUR 36 000 - 47 000; Plein temps

Résumé du poste

Inserm France, at IGBMC Strasbourg, seeks a postdoctoral researcher to study species-specific ADAT tRNA deaminase functions in cortical development using human iPSC- and mouse ESC-derived models, including 2D neural cells and 3D organoids carrying pathogenic variants.

The project runs for 30 months under Dr. Juliette Godin and collaboration with a bioinformatician, with opportunities for manuscript authorship and supervision of students.

Qualifications

• Ph.D in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or a related field, recently obtained.
• Experience with human iPSC culture and/or 2D/3D neural differentiation protocols is required.
• Proficiency in standard molecular and cell biology techniques (immunofluorescence, Western blot, qPCR, imaging).
• Familiarity with high-throughput sequencing approaches (RNA-seq, ribosome profiling) is a plus.
• Interest in neurodevelopment, neurodevelopmental disorders and translational control.
• Strong written and oral English communication, teamwork and adaptability.

Responsabilités

• Study species-specific ADAT functions in progenitors and neurons.
• Characterize tRNA and translational programs using sequencing data.
• Generate and analyze human iPSC-derived 2D/3D cortical models.
• Present findings at meetings and contribute to manuscripts and reporting.

Connaissances

Human iPSC culture

2D/3D neural differentiation

Molecular biology techniques

English communication

Immunofluorescence & imaging

RNA-seq & ribosome profiling awareness

Formation

Ph.D in Cell Biology / Molecular Biology / Developmental Biology / Neuroscience

Outils

Immunofluorescence

Western blot

qPCR

EdU/pulse-chase labeling

MEA & calcium imaging

RNA-seq data analysis

Description du poste

POSTDOC_Species-Specific ADAT Function in Cortical Development_061_JG - H/F

About the position

We are looking for a highly motivated postdoctoral researcher to join the “Physiological and Pathological Mechanisms of Cortical Development” team led by Dr. Juliette Godin at the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Strasbourg, France. The Godin lab is a recognized expert in translational control during cortical development. The selected candidate will work under the direct supervision of Dr. Efil Bayam (CRCN Inserm), in the framework of the ANR-funded project SpeaDAT, which investigates the species-specific mechanisms of ADAT tRNA deaminase complex dysfunction in brain development. The postdoctoral researcher will study species-specific ADAT functions in progenitors and neurons and characterize impact of ADAT dysfunction on tRNAs and translational programs using human iPSC- and mouse ESCs -derived models, including 2D cortical neural stem cells/neurons and 3D cortical organoids carrying ADAT2 and ADAT3 pathogenic variants. This 30-month position is well suited to a recently graduated PhD experienced with human iPSC culture and/or 2D/3D neural differentiation protocols.

The candidate will generate and characterize human iPSC-derived 2D cortical neural stem cells, neurons and 3D cortical organoids carrying ADAT2 and ADAT3 pathogenic variants, assess cellular phenotypes (proliferation, cell cycle dynamics, progenitor identity, neuronal maturation and synaptic integration) using immunofluorescence, EdU/pulse-chase labeling and functional assays (MEA, calcium imaging) and analyze and interpret human mim-tRNA-seq and ribosome profiling data to characterize species-specific tRNA and translational programs in close collaboration with a bioinformatician.

Present research findings at team and consortium meetings and at national/international conferences, contribute to manuscript writing and to project reporting; contribute to the supervision of students.

Desired profile

Skills/Qualifications :

• Ph.D in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or a related field,recently obtained.
• Experience with human iPSC culture and/or 2D/3D neural differentiation protocolsis required.
• Proficiency in standard molecular and cell biology techniques (immunofluorescence, western blot, qPCR, imaging)
• Familiarity with high-throughput sequencing approaches (RNA-seq, ribosome profiling) is a plus
• Interest in neurodevelopment, neurodevelopmental disorders and translational control
• Fast learner, critical thinking, positive attitude, strong problem-solving skills and adaptability to new data and questions
• Good interpersonal skills and ability to work within an interdisciplinary, international consortium
• Strong written and oral communication skills in English
• Strong organizational skills, personal motivation and creativity

Required Experience : 0 - 2 years, fields: Cell biology, molecular biology, developmental biology, neuroscience, stem cell biology or a related field.

Position characteristics

Offer info

Published on 12/08/2026 Contractuel Catégorie A Fixed-term contract - 30 months Full time Experience preferred License not required > Master degree level PhD in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or a related field.

To be defined according to profile

As soon as possible