Postdoc: Species-Specific ADAT in Cortical Development

IGBMC - Institute of Genetics and Molecular and Cellular Biology; Strasbourg; On-site; EUR 30,000 - 36,000; Full time

Job summary

IGBMC - Institute of Genetics and Molecular and Cellular Biology in Strasbourg, France, invites applications for a post-doctoral position focused on species-specific mechanisms of ADAT dysfunction in cortical development. The role involves human iPSC- and mouse ESC-derived models to study tRNA modifications and translational control in neurodevelopment.

Applicants should hold a PhD in a relevant field, with experience in iPSC culture and neural differentiation, plus strong communication skills

Qualifications

• PhD in a relevant field; recently obtained.
• Experience with human iPSC culture and/or 2D/3D neural differentiation protocols is required.
• Familiarity with high-throughput sequencing approaches (RNA-seq, ribosome profiling) is a plus.
• Interest in neurodevelopment and translational control/epitranscriptomics.

Responsibilities

• Generate and characterize human iPSC and mouse ESC-derived 2D cortical neural stem cells, neurons and 3D cortical organoids carrying ADAT2/ADAT3 pathogenic variants;
• Assess cellular phenotypes using immunofluorescence, EdU labeling and functional assays;
• Analyze and interpret mim-tRNA-seq and ribosome profiling data;
• Present findings at meetings; contribute to manuscript writing and supervision of students.

Skills

English (fluent)

Autonomous

Fast learner

Strong organizational skills

Communication skills

Education

PhD in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or related field

Tools

Immunofluorescence

Western blot

qPCR

Imaging

Job description

IGBMC - Institute of Genetics and Molecular and Cellular Biology in Strasbourg, France, invites applications for a post-doctoral position focused on species-specific mechanisms of ADAT dysfunction in cortical development. The role involves human iPSC- and mouse ESC-derived models to study tRNA modifications and translational control in neurodevelopment.

Applicants should hold a PhD in a relevant field, with experience in iPSC culture and neural differentiation, plus strong communication skills