Postdoc: Species-Specific ADAT in Cortical Development

Institut de Génétique et Biologie Moléculaire et Cellulaire; Illkirch-Graffenstaden; Sur place; EUR 33 000 - 39 000; Plein temps

Résumé du poste

The Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France, invites applications for a 30‑month post‑doctoral position focused on species‑specific mechanisms of ADAT dysfunction in brain development. The project uses human iPSC‑based 2D/3D models and mouse ESC derivatives to study translational control in cortical development.

Successful candidates will work in a collaborative, international environment within the SpeaDAT project; expertise in iPSC culture,

Qualifications

• PhD in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or a related field, recently obtained.
• Experience with human iPSC culture and/or 2D/3D neural differentiation protocols required.
• Proficiency in immunofluorescence, western blot, qPCR and imaging.
• Familiarity with high‑throughput sequencing approaches (RNA‑seq, ribosome profiling) is a plus.
• Strong English communication and ability to work in an interdisciplinary, international setting.

Responsabilités

• Generate and characterize human iPSC and mouse ESC‑derived 2D cortical neural cells and 3D organoids with ADAT variants.
• Assess cellular phenotypes (proliferation, cell cycle, progenitor identity, neuronal maturation) using imaging and labeling.
• Analyze and interpret sequencing data to define species‑specific translational programs.
• Present findings at team meetings and conferences; contribute to manuscript writing and project reporting.
• Collaborate with a bioinformatician and supervise students in the lab.

Connaissances

iPSC culture

neural differentiation

immunofluorescence

western blot

qPCR

imaging

RNA-seq

ribosome profiling

Formation

PhD in Cell Biology, Molecular Biology, Developmental Biology, Neuroscience or related field

Description du poste

The Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France, invites applications for a 30‑month post‑doctoral position focused on species‑specific mechanisms of ADAT dysfunction in brain development. The project uses human iPSC‑based 2D/3D models and mouse ESC derivatives to study translational control in cortical development.

Successful candidates will work in a collaborative, international environment within the SpeaDAT project; expertise in iPSC culture,