Postdoctoral position - Nicol & Fassier Lab

Institut de la vision; Paris; Hybride; EUR 38 000 - 48 000; Plein temps

Résumé du poste

The Nicol & Fassier lab at Institut de la Vision (Paris, France) is seeking a postdoctoral fellow to join the Mechanisms of sensory map development team for an ANR-funded project led by Melody Atkins. The successful candidate will use live videomicroscopy, optogenetics or TIRF imaging with engineered molecular tools to study neuronal migration and primary cilium signaling.

A PhD in cell biology or neuroscience is required; experience with live cell imaging is welcome; position funded for 3 years

Qualifications

• PhD in cell biology or neuroscience.
• Experience with live cell imaging is welcome.
• Ability to work independently for experimental design.

Responsabilités

• Use cutting-edge imaging to investigate neuronal migration and map development.
• Apply live videomicroscopy, optogenetics or TIRF imaging with molecular tools.
• Contribute to a three-year ANR-funded project.

Connaissances

Live imaging

Primary cell culture

Experimental design

Independence in work

Teamwork

Optogenetics

TIRF imaging

Formation

PhD in cell biology or neuroscience

Outils

TIRF imaging

Optogenetics

Description du poste

The Nicol & Fassier lab at the Institut de la Vision (Paris, France) is seeking a postdoctoral fellow to join the “Mechanisms of sensory map development” team and contribute to an ANR-funded project led by Melody Atkins . The Institut de la Vision is part of Sorbonne University, CNRS and Inserm, and offers a highly multidisciplinary environment with teams active in fields ranging from theoretical neuroscience or developmental biology to the development of retinal prostheses.

Our team investigates the cellular and molecular mechanisms leading to the accurate wiring of neuronal networks. The successful candidate will join our ANR-funded MASTERCIL project, which aims to investigate the role of the primary cilium as a major command centre of neuronal migration. The primary cilium is a sensory antenna located close to soma at the rear of migrating neurons. Our recent work has identified a role for second messenger signals elicited locally within the primary cilium as the steering wheel of migrating neurons. Remarkably, this guiding role is traditionally attributed to the growth cone at the cell front, that actively explores its environment and pulls the soma forwards. The MASTERCIL project aims to identify the specific roles of the primary cilium and growth cone command centres on neuronal migration and to investigate how the two command centres communicate to instruct migration.

Missions

The successful candidate will address these challenging questions using different cutting-edge imaging techniques, including live videomicroscopy, optogenetics or TIRF imaging, combined with genetically encoded molecular tools enabling the manipulation of subcellular signals in different in vitro and ex vivo migration models.

The successful applicant should hold a PhD in cell biology or neuroscience.

Previous experience in live cell imaging and/or primary cell cultures is welcome but not required.

The candidate is expected to work independently for the design and realisation of the experiments.

The position is funded for 3 years, starting in April 2027.