Postdoc: NF-κB Signaling in Myeloma & MCL

Biopractify

Paris

Hybrid

EUR 28,000 - 38,000

Full time

14 days+

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Benefits offered by this job

Monthly transport pass (75%)

Job summary

The Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris) invites applications for a Postdoctoral Researcher to investigate NF-κB signaling in hematological malignancies, focusing on multiple myeloma and mantle cell lymphoma. This three-year fixed-term role is funded by INCa and located at the Pitié-Salpêtrière campus in Paris.

You will work in a multidisciplinary environment, using molecular biology, proteomics, and cellular pharmacology, with access to patient samples and

Qualifications

PhD in Cell Biology, Molecular Biology, Cancer Biology, Pharmacology or related biomedical discipline.
Experience with cancer biology, immunology, inflammation, infection, NF-κB signaling, proteasome/ubiquitination, or hematology is advantageous.

Responsibilities

Investigate NF-κB pathway regulation in multiple myeloma and mantle cell lymphoma.
Identify and characterize novel therapeutic targets affecting NF-κB activation.
Work with molecular biology, proteomics, and translational research approaches; analyze patient samples.

Education

PhD in Cell/Molecular/Cancer Biology or Pharmacology

Tools

CRISPR/Cas9

Proteomics

Flow Cytometry

Western Blotting

Cell Culture

Job description

The Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris) is recruiting a Postdoctoral Researcher for a 3-year fixed-term position to investigate new therapeutic strategies targeting the NF-κB pathway in multiple myeloma and mantle cell lymphoma. The project is funded by the French National Cancer Institute (INCa).

The project aims to identify and characterize new therapeutic targets regulating NF-κB activation in hematological malignancies, with a particular focus on multiple myeloma and mantle cell lymphoma.

The research will investigate:

Ubiquitin-proteasome system and its regulatory mechanisms
Supramolecular complexes involved in NF-κB signaling
Bortezomib-sensitive and bortezomib-resistant cancer models
Patient samples from individuals with multiple myeloma

The project combines molecular biology, cancer research, immunology, inflammation, cellular pharmacology, and proteomics to identify potential therapeutic strategies.

Study the molecular mechanisms regulating NF-κB activation in response to pro-inflammatory cytokines and identify potential therapeutic regulators.

Proteasome & Ubiquitination

Investigate the ubiquitin-proteasome system, proteasome-associated regulators, and their role in cancer-associated signaling.

Multiple Myeloma & Mantle Cell Lymphoma

Evaluate therapeutic targets and pharmacological compounds in multiple myeloma and mantle cell lymphoma models, including drug-resistant systems.

Explore mechanisms connecting inflammation, immune signaling, infection, and cancer biology to identify clinically relevant therapeutic opportunities.

Translational Research

Assess the relevance of experimental findings using patient samples from multiple myeloma, alongside collaborations with clinical and research partners.

Experience with several of the following techniques will be valued:

Cell culture
Western blotting
CRISPR/Cas9
Proteomics
Flow cytometry
Molecular and cellular biology

Experience in cancer biology, immunology, inflammation, infection, NF-κB signaling, proteasome/ubiquitination, or hematology would be particularly relevant.

Applicants should hold a PhD in one of the following areas:

Cell Biology
Molecular Biology
Cancer Biology
Pharmacology
Related biological or biomedical disciplines

The ideal candidate should demonstrate:

Strong scientific curiosity
Rigorous and independent research ability
Ability to develop and execute scientific hypotheses
Strong interest in cancer, immunology, inflammation, or molecular signaling
Ability to work effectively within a multidisciplinary research environment

The postdoctoral researcher will work within a multidisciplinary research environment at CIMI-Paris, with collaborations involving:

Toulouse Cancer Research Center
Clinical and research teams associated with Sorbonne Université

CIMI-Paris is a joint research unit affiliated with Sorbonne Université, INSERM, and CNRS, located at the Pitié-Salpêtrière campus in Paris.

🌟 What You’ll Gain

Opportunity to work on cancer and immunology research
Advanced experience in NF-κB signaling
Exposure to ubiquitination and proteasome biology
Hands-on experience with molecular and cellular techniques
Experience with pharmacological cancer models
Opportunity to work with patient-derived samples
Interdisciplinary collaborations across leading research institutions
Experience in translational research connecting molecular mechanisms with therapeutic strategies

💰 Salary & Position Details

Position: Postdoctoral Researcher

Contract: 3-Year Fixed-Term Contract

Salary: From €2,997.20 gross/month, depending on professional experience

Additional Benefit: Monthly transport pass participation of 75%

Funding: French National Cancer Institute (INCa)

Research Focus: NF-κB | Cancer | Immunology | Multiple Myeloma | Mantle Cell Lymphoma

Applicants are encouraged to highlight their relevant research experience and technical expertise in their application.

Position: Postdoctoral Researcher

Location: Paris, France

Contract: 3-Year Fixed-Term Contract

Salary: From €2,997.20 Gross/Month

Additional Benefit: 75% Monthly Transport Pass

Funding: French National Cancer Institute (INCa)

Research Areas: NF-κB Signaling | Cancer Biology | Immunology | Multiple Myeloma | Mantle Cell Lymphoma

Application Mode: Email

#Postdoc #PostdoctoralPosition #PostdocFrance #CIMIParis #INSERM #CNRS #SorbonneUniversite #CancerBiology #Immunology #NFkB #MultipleMyeloma #MantleCellLymphoma #Proteasome

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